Role of the membrane potential in mitochondrial protein unfolding ...

Newly synthesized mitochondrial precursor proteins have to become unfolded to cross the mitochondrial membranes. This unfolding is achieved ...

Protein unfolding by the mitochondrial membrane potential - Nature

Two candidates for the unfolding activity are the electrical potential across the inner mitochondrial membrane and mitochondrial Hsp70 in the ...

Membrane Potential-Driven Protein Import into Mitochondria

The transport of preproteins into or across the mitochondrial inner membrane requires the membrane potential Δψ across this membrane. Two roles of Δψ in the ...

Membrane Potential-Driven Protein Import into Mitochondria

Two roles of Δψ in the import of cleavable preproteins have been described: an electrophoretic effect on the positively charged matrix-targeting ...

The Force Exerted by the Membrane Potential during Protein Import ...

The force exerted on a targeting sequence by the electrical potential across the inner mitochondrial membrane is calculated on the basis of continuum ...

Role of the membrane potential in mitochondrial protein unfolding ...

Role of the membrane potential in mitochondrial protein unfolding and import. ... Sci. Rep. ... 膜电位在线粒体蛋白展开和导入中的作用。新合成的 ...

The Force Exerted by the Membrane Potential during Protein Import ...

The unraveling occurs when the targeting sequence engages the unfolding machin- ery associated with the inner mitochondrial membrane whereas the structured ...

Role of the membrane potential in mitochondrial protein unfolding ...

Newly synthesized mitochondrial precursor proteins have to become unfolded to cross the mitochondrial membranes. This unfolding is achieved primarily by ...

Role of the membrane potential in mitochondrial protein unfolding ...

This unfolding is achieved primarily by mitochondrial Hsp70 (mtHsp70) for presequence-containing precursor proteins. However, the membrane potential across the ...

Decreased Mitochondrial Membrane Potential Activates the ...

The mitochondrial unfolded protein response (UPRmt) is a specific program that responds to imbalances in nuclear and mitochondrial gene expression. Mounting ...

Protein unfolding by mitochondria: The Hsp70 import motor

The central component of the mitochondrial import motor, the matrix heat shock protein 70, functions by both pulling and holding the preproteins. Introduction.

Powering mitochondrial protein import - Molecular and Cell Biology |

matrix, but also the electrical membrane potential across the inner membrane can actively unfold preproteins via ... 2c). Role of the membrane potential. The ...

Protein unfolding by the mitochondrial membrane potential

Regardless, the mem- brane potential unravels precursor proteins by pulling at their charged targeting sequences. What is the function of ...

Open questions on the mitochondrial unfolded protein response

Upon proteomic imbalances or defects in mitochondrial functions, protective cellular responses are activated to restore and maintain organellar ...

Targeting and Insertion of Membrane Proteins in Mitochondria

Mitochondrial membrane proteins play an essential role in all major mitochondrial functions. The respiratory complexes of the inner membrane are key for the ...

Signaling the mitochondrial unfolded protein response - ScienceDirect

The UPR mt is a mitochondria-to-nuclear signal transduction pathway resulting in the induction of mitochondrial protective genes including mitochondrial ...

Two distinct membrane potential–dependent steps drive ...

In this study, we show that mitochondrial matrix proteins display surprisingly different dependencies on the Δψ. However, a precursor's ...

The different axes of the mammalian mitochondrial unfolded protein ...

Mitochondria are sensitive to numerous environmental stresses, which can lead to activation of mitochondrial stress responses (MSRs).

Molecular Chaperones and Mitochondrial Protein Folding

Precursor proteins destined for the mitochondrial matrix traverse inner and outer organelle membranes in an extended conformation.

Mechanisms of Protein Import into Mitochondria: Current Biology

The import machinery ensures that proteins earmarked for the mitochondrion are recognised and delivered to the organelle, transported across membranes, sorted ...