Role of tumor–host interactions in interstitial diffusion of ...

Role of tumor–host interactions in interstitial diffusion of ... - PNAS

We postulate that diffusion of macromolecules will vary with tumor type as well as anatomical location.

Role of tumor-host interactions in interstitial diffusion of ... - PubMed

We postulate that diffusion of macromolecules will vary with tumor type as well as anatomical location.

Role of tumor–host interactions in interstitial diffusion of ... - PNAS

The slower diffusion in DC tumors was associated with a higher density of host stromal cells that synthesize and organize collagen type I. Our results point to ...

Role of Tumor-Host Interactions in Interstitial Diffusion of ...

The large size of many novel therapeutics impairs their transport through the tumor extracellular matrix and thus limits their therapeutic effectiveness.

[PDF] Role of tumor–host interactions in interstitial diffusion of ...

The results point to the necessity of developing site-specific drug carriers to improve the delivery of molecular medicine to solid tumors.

Role of tumor–host interactions in interstitial diffusion of ... - Altmetric

Role of tumor–host interactions in interstitial diffusion of macromolecules: Cranial vs. subcutaneous tumors · Proceedings of the National Academy of Sciences of ...

Role of tumor-host interactions in interstitial diffusion of ...

Role of tumor-host interactions in interstitial diffusion of macromolecules: Cranial vs. subcutaneous tumors. Alain Pluen, Yves Boucher, Saroja Ramanujan ...

OpenAlex | Role of tumor–host interactions in interstitial diffusion of ...

Abstract: The large size of many novel therapeutics impairs their transport through the tumor extracellular matrix and thus limits their therapeutic ...

(PDF) Pluen A, Boucher Y, Ramanujan S, McKee TD, Gohongi T, di ...

Furthermore, because the characteristics of the extracellular matrix largely depend on the tumor-host interactions, we postulate that diffusion of ...

Publications - Steele Labs

Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors. Proc Natl Acad Sci U S A. 2001;98(8):4628-33 ...

Cellular Interactions in the Tumor Microenvironment - PubMed Central

Fibroblasts represent the most abundant cells of the tumor stroma and play a critical role in tumor growth, survival, proliferation, migration, invasion, and ...

Lab Base :: Publications - Steele Labs

Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors. Proc Natl Acad Sci U S A. 2001;98(8):4628-33 ...

DELIVERY OF MOLECULAR MEDICINE TO TUMORS III

Berk, R.K. Jain, "Role of Tumor-Host Interactions in Interstitial Diffusion of Macromolecules: Cranial vs. Subcutaneous tumors," PNAS, 98: 4628-4633 (2001).

Role of Microenvironment on Gene Expression, Angiogenesis and ...

Both stromal cells and tumor cells participate in the formation of this milieu, and the microenvironment, which includes the expression of positive and negative ...

Fluid mechanics in circulating tumour cells: Role in metastasis and ...

Because collagen I boosts mesenchymal motility, cancer cells could travel in the opposite direction of convective flow. The flow of interstitial fluid works in ...

Diffusion and Convection in Collagen Gels - Cell Press

34. Pluen, A. ∙ Boucher, Y. ∙ Ramanujan, S. ... Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors.

Comparison of IgG diffusion and extracellular matrix composition in ...

Comparison of in vitro vs in vivo results suggests an over-riding role of host stromal cells in extracellular matrix production subjected to ...

Role of Host Microenvironment in Angiogenesis and Microvascular ...

Collectively, host microenvironment is an important determinant of tumor gene expression and microvascular functions, and, thus, orthotopic breast tumor models ...

Role of extracellular matrix assembly in interstitial transport in solid ...

Role of tumor–host interactions in interstitial diffusion of macromolecules: Cranial vs. subcutaneous tumors · A. PluenY. Boucher +8 authors. R. Jain.

Role of Extracellular Matrix Assembly in Interstitial Transport in Solid ...

The extracellular matrix (ECM) may contribute to the drug resistance of a solid tumor by preventing the penetration of therapeutic agents.