Roles of metabolic compartmentalization by astrocytes and neurons ...

[Roles of metabolic compartmentalization by astrocytes and neurons ...

Mitochondrial dysfunction has been implicated in the pathogenesis of both idiopathic and familial Parkinson's disease (PD). Dopamine neurons in the ...

Metabolic compartmentalization between astroglia and neurons in ...

In particular, the astroglial cellular metabolic compartment exerts supportive roles in dedicating neurons to the generation of action ...

Astrocyte metabolism and signaling pathways in the CNS - Frontiers

Glucose metabolism in astrocytes provides the necessary metabolic substrate to respond to the energy needs of neurons, ensuring their normal functions. FIGURE 1.

1: Neuron and astrocyte metabolism - Medicine LibreTexts

Considering the role of astrocytic glucose-derived lactate in fueling neuronal energy needs, this coupling of these compartmentalized metabolic ...

Roles of metabolic compartmentalization by astrocytes and neurons ...

ATP production in neuronal cells is dependent on mitochondrial glucose oxidation, and reactive oxygen species (ROS) production associated with neuronal ...

1. Neuron and astrocyte metabolism - Pressbooks at Virginia Tech

Within the brain, astrocytes outnumber neurons but have reduced demand for ATP. Although astrocytes display lower oxidative rates when compared to neurons, they ...

Neuron–astrocyte metabolic coupling facilitates spinal plasticity and ...

Metabolic coupling between astrocytes and neurons has been implicated in neuronal plasticity and memory formation in the central nervous system, ...

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic ...

One of the best-characterized functions of astrocytes is the rapid removal of neurotransmitters released into the synaptic cleft, an essential ...

Astrocyte-Neuron Metabolic Crosstalk in Neurodegeneration

Besides their role in brain development, astrocytic processes extensively ensheath synapses and participate in neurotransmitter removal from the synaptic cleft, ...

Neuronal-Astrocyte Metabolic Interactions - Oxford Academic

Astrocyte functions include buffering the extracellular space, providing substrates to neurons, interchanging glutamate and glutamine for synaptic transmission ...

Functional metabolic interactions of human neuron-astrocyte 3D in ...

Cell metabolic specialization was further demonstrated by higher pyruvate carboxylase-derived labeling in glutamine than in glutamate, ...

Astrocytes as metabolic suppliers to support neuronal activity and ...

Energy metabolism is essential for brain function. In recent years, lactate shuttling between astrocytes and neurons has become a fundamental concept of ...

Brain Energy Metabolism: Astrocytes in Neurodegenerative Diseases

Astrocytes provide metabolic substrates for neurons, maintain high activity of neuron, and facilitate information transmission of neurons. This ...

Brain Metabolism in Health and Neurodegeneration - MDPI

Astrocytes, which interface with neurons and blood vessels, play a crucial role in coordinating the brain's metabolic activity, and their dysfunction can have ...

Metabolic switch in the aging astrocyte supported via integrative ...

Dysregulated central-energy metabolism is a hallmark of brain aging. Supplying enough energy for neurotransmission relies on the neuron-astrocyte metabolic ...

Metabolic compartmentalization in the human cortex and ...

... notion of metabolic compartmentalization between astrocytes and neurons, whereby lactate produced by astrocytes could be oxidized by neurons.

Metabolic compartmentalization between astroglia and neurons in ...

New roles for astrocytes: Redefining the functional architecture of the brain · Biology, Medicine. Trends in Neurosciences · 2003.

Metabolic Reprogramming of Astrocytes in Pathological Conditions

Astrocytes play a pivotal role in maintaining brain energy homeostasis, supporting neuronal function through glycolysis and lipid metabolism.

Aspects of Astrocyte Energy Metabolism, Amino Acid ...

Astrocytes are key players in brain function; they are intimately involved in neuronal signalling processes and their metabolism is tightly coupled to that ...

Energy Metabolism in Astrocytes: High Rate of Oxidative Metabolism ...

Astrocytic metabolic compartmentation arises from their complex ultrastructure; astrocytes have high oxidative rates plus dependence on glycolysis and ...