SUBCELLULAR FORCE IMBALANCE IN ACTIN BUNDLES ...

Subcellular Force Imbalance in Actin Bundles Induces Nuclear ...

Because the actin cap fibers are anchored to the nucleus at LINC complexes, this effectively isolates the two fiber ends, thereby maintaining ...

Subcellular Force Imbalance in Actin Bundles Induces Nuclear ...

Chiam, Bioinformatics Institute, 138671 Singapore, Singapore, E-mail: [email protected] star.edu.sg. KEYWORDS: Durotaxis, traction force, nano/micro pillars, ...

Subcellular Force Imbalance in Actin Bundles Induces Nuclear ...

Request PDF | Subcellular Force Imbalance in Actin Bundles Induces Nuclear Repositioning and Durotaxis | Durotaxis is a phenomenon in which ...

SUBCELLULAR FORCE IMBALANCE IN ACTIN BUNDLES ...

Keywords: Durotaxis, LINC complex, Pillar array with stiffness gradient ; Issue Date: 19-Jan-2022 ; Citation: MYEONGJUN JUN (2022-01-19). SUBCELLULAR FORCE ...

Subcellular Force Imbalance in Actin Bundles Induces Nuclear ...

Subcellular Force Imbalance in Actin Bundles Induces Nuclear Repositioning and Durotaxis. https://doi.org/10.1021/acsami.3c07546 ·. Journal: ACS Applied ...

Force Production by a Bundle of Growing Actin Filaments Is Limited ...

Bundles of actin filaments are central to a large variety of cellular structures such as filopodia, stress fibers, cytokinetic rings, and focal adhesions. The ...

Subcellular Force Imbalance in Actin Bundles Induces ... - X-MOL

Subcellular Force Imbalance in Actin Bundles Induces Nuclear Repositioning and Durotaxis. ACS Appl. Mater. Interfaces Pub Date : 2023-09-06. DOI : 10.1021 ...

Actin bundle architecture and mechanics regulate myosin II force ...

Simulations reveal that these locations of stalled myosin motion correspond to sustained, high forces in regions of balanced actin filament polarity. By ...

Actin-based force generation and cell adhesion in tissue ...

Recent evidence suggests that force imbalances may be genetically patterned by the same signaling mechanisms involved in cell-fate specification ...

Actin Bundle Nanomechanics and Organization Are Modulated by ...

Although the roles of cations and macromolecular crowding in the mechanics and organization of actin bundles have been independently established ...

Actin Bundles Dynamics and Architecture - MDPI

It is indispensable for driving many cellular processes, including cell migration, cytokinesis, vesicle transport, and contractile force generation [3]. The ...

Caldesmon controls stress fiber force-balance through dynamic ...

Depletion of Caldesmon results in aberrant lateral movement of myosin-II filaments along actin bundles, leading to irregular myosin distribution ...

Actin Dynamics, Architecture, and Mechanics in Cell Motility

Indeed, short stiff bundles stay straight as they apply a force against a load, whereas long actin bundles have a tendency to buckle and deform themselves ...

Liquid behavior of cross-linked actin bundles - PNAS

The mechanical properties of actin assemblies regulate force generation and transmission to dynamically control morphogenic processes from the ...

Generation of contractile actomyosin bundles depends on ... - eLife

Importantly, this myosin II-derived force inhibits vectorial actin polymerization at focal adhesions through AMPK-mediated phosphorylation of ...

How are actin filaments distributed in cells and tissues?

Actin-associated myosin motor proteins use ATP hydrolysis to exert forces against the stress fibers during muscle contraction; the energy of ...

Branched actin networks push against each other at adherens ...

In contrast, actin–NMII bundles are located more distally from the VE-cadherin–rich zone. After Arp2/3 complex inhibition, linear AJs split, ...

Actin bundle architecture and mechanics regulate myosin II force ...

Simulations reveal that these locations of stalled myosin motion correspond to sustained, high forces in regions of balanced actin filament ...

Tensile force-induced cytoskeletal remodeling: Mechanics before ...

We found that actin network remodels through a two-step process in which rapid alignment of actin filaments is followed by slower actin bundling.

Confinement Geometry Tunes Fascin-Actin Bundle Structures and ...

The dynamic organization of actin networks is regulated by a number of accessory proteins that coordinate actin polymerization/de-polymerization ...