SUMOylation directly targets Ci and promotes Ci activity in terms of...

Using this approach, we find that CG11180 and SUMO are required in somatic cells of adult testes, and that reduction of either protein causes formation of germ ...

Download scientific diagram | SUMOylation directly targets Ci and promotes Ci activity in terms of CySC proliferation. (A) Western blot assay showing that ...

Ubiquitination and SUMOylation in Telomere Maintenance and ...

Ubiquitination and SUMOylation are also important for promoting telomere elongation by ALT in cells without telomerase activity. The shelterin protein TRF1 has ...

Regulation of Smoothened Trafficking and Hedgehog Signaling by ...

Sumoylation is a dynamic process, and removal of SUMO molecules (desumoylation) from target proteins is accomplished by SUMO-specific ...

SUMOylation promotes protective responses to DNA‐protein ...

SUMOylation directly targets defined DNMT1 DPCs ... While formaldehyde is a potent inducer of DPCs, it also generates other forms of ...

SUMOylation promotes protective responses to DNA‐protein ... - NCBI

SUMOylation directly targets defined DNMT1 DPCs ... While formaldehyde is a potent inducer of DPCs, it also generates other forms of ...

The emerging roles of SUMOylation in the tumor microenvironment ...

UBC9/PIASy-mediated SUMOylation decreases sirtuin 1 (SIRT1) and increases transcriptional repression activity of SLUG, predicting more invasive ...

SUMO regulates the activity of Smoothened and Costal-2 in ... - Nature

To explore whether SUMO pathway plays a role in Hh signaling, we collected RNAi lines from either Vienna Drosophila Research Center (VDRC) or ...

Smt3 - Society for Developmental Biology

Importantly, SUMO pathway directly regulates the SUMOylation of Hh pathway transcriptional factor, Cubitus interruptus (Ci), which is required ...

SUMOylation of PHYTOCHROME INTERACTING FACTOR 3 ...

We also found that the SUMO acceptor site mutant PIF3(K13R) binds more strongly to the target promoters than its SUMOylated, wild-type ...

SUMOylation and the HSF1-Regulated Chaperone Network ...

We investigated SUMO signal transduction at the proteomic and functional level during the HSR in cells depleted of proteostasis network ...

SUMOylation inhibition enhances multiple myeloma sensitivity to ...

SUMOylation inhibition reduced DOT1L with decreased methylation of histone H3 lysine 79, to suppress IRF4 gene transcription. SUMOylation ...

SUMO1 modification of methyltransferase-like 3 promotes tumor ...

SUMOylation, the covalent modification of a protein by a small ubiquitin-like modifier (SUMO) peptide on a lysine residue, has emerged as an important ...

SUMOylation and the HSF1-Regulated Chaperone Network ...

expect higher auto-SUMOylation activity of SUMO E3 ligases ... Because SUMO modifications are not known to directly target proteins ...

Emerging roles of the SUMO pathway in mitosis - Cell Division

Finally, growing evidence suggests that SUMOylation is a downstream target of regulation through Ran, a small GTPase with important functions in ...

PDSM, a motif for phosphorylation-dependent SUMO modification

However, apart from the ΨKxE tetrapeptide, no common regulatory motifs involved in SUMO conjugation are known (1). The SUMO family consists of four members, ...

The Ubiquitin-Like SUMO System and Heart Function - AHA Journals

SUMOylation targets a wide variety of cellular regulators and thereby affects a multitude of different cellular processes. SUMO/sentrin-specific ...

SUMO conjugation – a mechanistic view - De Gruyter

Sumoylation is highly dynamic due to the opposing activities of SUMO conjugation and SUMO deconjugation. SUMO conjugation is performed by the ...

Protein SUMOylation modification and its associations with disease

The SUMOylated MAFB promotes colorectal cancer tumorigenesis through cell cycle regulation [43]. Similarly, SUMOylation of Akt is required for ...

SUMO protein - Wikipedia

In molecular biology, SUMO (Small Ubiquitin-like Modifier) proteins are a family of small proteins that are covalently attached to and detached from other ...