Scientists Identify Protein That's Crucial to Tumor Cells' Metabolism ...

By developing a new computational tool, researchers have identified a potential target for anti-cancer therapies that could simultaneously ...

Scientists identify protein that's crucial to tumor cells' metabolism

ESRRA inhibition was safe when tested in mice, and its effects on energy metabolism were focused on cancer cells. The scientists also ...

Researchers discover protein crucial to T cell metabolism and anti ...

Researchers at The University of Texas MD Anderson Cancer Center have discovered that a protein called NF-kappa B-inducing kinase (NIK) is ...

NIH study visualizes proteins involved in cancer cell metabolism

Cryo-EM methods can determine structures of small proteins bound to potential drug candidates. Improving resolutions in atomic detail of ...

Scientists discover protein that eradicates cancer and boosts the ...

This tool was designed to pinpoint proteins that could disrupt cancer cell metabolism while simultaneously promoting a robust immune response in ...

Amino acid metabolism in tumor biology and therapy - Nature

Although glycine is a non-essential amino acid, experiments have shown that limiting the supply of exogenous glycine induces tumor cells ...

Targeting cancer metabolism in the era of precision oncology - Nature

1), proliferating cells import nutrients and amino acids that stimulate the mammalian target of rapamycin complex 1 (mTORC1) and activate ...

Cancer metabolism: Key players in metabolic reprogramming - PMC

Over 80 years ago, Warburg discovered that cancer cells generate ATP through the glycolytic pathway, even in the presence of oxygen. The finding of this ...

Scientists find link between cancer metabolism and cellular ...

... cancer cell's form and shape and its metabolic capabilities. "This is a very important discovery in that it indicates that the highly motile actin - long ...

Cancer Metabolism and Signaling in the Tumor Microenvironment

Research from Richard Possemato, PhD, associate professor in pathology at the NYU Grossman School of Medicine, showed that iron-sulfur clusters ...

The hallmarks of cancer metabolism: Still emerging - ScienceDirect

Besides the principal low-molecular weight nutrients—i.e., glucose and amino acids—cancer cells are able to utilize a wide spectrum of ...

Tumors hide from the immune system with help from this protein

“The upshot is that SETDB1 loss has two separate and profound effects, both of which help the immune system detect and kill cancer cells.” The ...

The cancer metabolic reprogramming and immune response

Subsequently, more and more researchers have found that the aberrant metabolites or intermediates of cancer metabolism could have an important ...

Fundamentals of cancer metabolism | Science Advances

Tumor cells have aberrant activation of mTORC1 that induces an anabolic growth program resulting in nucleotide, protein, and lipid synthesis.

Researchers decipher how immune cells spot cancer's ...

"The fact that cancer cells have a profoundly altered metabolism makes them recognizable to MR1T cells," adds Dr. Lucia Mori, who was involved ...

Metabolic collaboration between cells in the tumor ...

The tumor microenvironment (TME) consists of many different cell types that share a common influx of metabolites from the blood, and its leaky blood vessels ...

Tumor Cell Metabolism: Cancer's Achilles' Heel - ScienceDirect.com

Cancer cells often manifest resistance against mitochondrial membrane permeabilization (MMP), which is one of the decisive steps of apoptosis (Kroemer et al., ...

Glutamine blockade induces divergent metabolic programs to ...

Glutamine is essential for tumor growth and has long been an attractive therapeutic target for cancer researchers. Some attempts at blocking glutamine ...

New Insights into Cellular Metabolism with Issam Ben-Sahra, PhD

... cellular metabolism and potentially identify new targets for cancer and metabolic diseases such as obesity. The discovery, published in the ...

How cancer cells fuel their growth | MIT News

Scientists report that amino acids, not sugar, supply most building blocks for cancerous tumor cells ... metabolic strategy known as ...