Scientists identify mechanism behind statin|induced muscle weakness

Scientists identify mechanism behind statin-induced muscle weakness

New research suggests that muscle weakness and related side effects that can arise from statin use is likely due to the drug's effect on the energy production ...

Scientists identify potential cause of statin-related muscle pain - BHF

Unregulated calcium leaks may cause damage to muscle cells, potentially leading to muscle pain and weakness. The researchers suggest that in ...

Statin-Associated Myopathy: Emphasis on Mechanisms and ...

SAMS, which range from mild-to-moderate muscle pain, weakness, or fatigue to potentially life-threatening rhabdomyolysis, are reported by 10% to 25% of patients ...

Statin-induced myalgia and myositis: an update on pathogenesis ...

As a general rule, in a high-risk patient (e.g. previous myocardial infarction) who has myalgia with normal serum CK values and no muscle weakness, we do not ...

Mechanisms of statin-associated skeletal muscle-associated ...

Importantly, SAMS are a common reason for stopping the treatment with statins. Statin-associated muscular symptoms include fatigue, weakness and pain, possibly ...

Scientists identify potential cause of statin-related muscle pain

Unregulated calcium leaks may cause damage to muscle cells, potentially leading to muscle pain and weakness. What is this? Report Ad. The ...

Mechanisms of Statin-Induced Myopathy - AHA Journals

... mechanism(s) underlying statin-induced myopathy remain controversial and ... induced muscle damage and statin treatment may be identified.

Scientists identify gene responsible for statin-induced muscle pain

Finally, the authors tested the drug in zebra fish. They showed that just as in mammalian muscle cell culture, lovastatin led to muscle damage, ...

Pathophysiological mechanisms of statin‐associated myopathies ...

Creatine kinase (CK) is commonly used as serum marker to define skeletal muscle damage and its severity. However, myopathy can occur without CK ...

A Mechanism for Statin-Induced Susceptibility to Myopathy

This includes mild to moderate muscle symptoms and/or signs (myalgia: muscle pain with stiffness and weakness), as well as more severe potentially life- ...

Rare disease informs mechanism and possible treatment of statin ...

While most individuals with statin-induced myopathy improved after discontinuation of the offending drug, others had persistent muscle weakness ...

Statin-associated muscle symptoms: impact on statin therapy ...

Discomfort and weakness typically occur early (within 4–6 weeks after starting statin therapy22), but may still occur after many years of treatment. Onset of ...

Statin-induced myopathic changes in primary human muscle cells ...

Although skeletal muscle damage has been studied in mice, it is unknown whether the same or different mechanisms underlie the various myopathic ...

Effects of Statins on Skeletal Muscle: A Perspective for Physical ...

The side effects most commonly associated with statin use involve muscle cramping, soreness, fatigue, weakness, and, in rare cases, rapid muscle breakdown that ...

Statin Toxicity | Circulation Research - AHA Journals

Noninflammatory myopathy presents as muscle weakness/pain with elevated CK, but no inflammation on biopsy, and has been suggested to be caused ...

Statin-Induced Myopathy: Types, Symptoms, and Risk Factors

stiffness. Symptoms of rhabdomyolysis include: severe muscle pain throughout your entire body; dark urine; muscle weakness; kidney damage.

Scientists Identify Mechanism of Statin-Induced Muscle Weakness

Research suggests that muscle weakness and related side effects that can arise from statin use is likely due to the drug's effect on the energy ...

Statin-induced myopathy: Definition, symptoms and treatment

A side effect of statins that some people report is myopathy, a group of disorders that cause muscle pain and weakness.

Statin-induced autoimmune myositis: a proposal of an “experience ...

In some patients, muscle weakness persisted even after the muscle enzyme levels have returned within the normal range [27]. Symptoms resolution ...

Rhabdomyolysis from statins: What's the risk? - Mayo Clinic

How do you know if you have rhabdomyolysis from statin use, and how likely is it? · Severe muscle aching throughout the entire body · Muscle weakness · Dark or ...