Searching for clues to how RNA triggers the immune system

mRNA is short for messenger RNA. It is one of several different types of RNA and its role is to deliver the recipe for making proteins to the ...

mRNA Victoria on LinkedIn: Searching for clues to how RNA triggers ...

This SARS-CoV-2 study looks at multiomics and the immune response (innate and adaptive) in participants age 18 to 96 years old who were hospitalized. The major ...

Immunological research using RNA interference technology - NCBI

Dendritic cells provide an essential link between the innate and adaptive immune responses, as they are the most potent activators of the adaptive immune system ...

RNA interference in biology and disease - PMC

Activation of this innate immune response is efficiently triggered by dsRNA, a pathogen-associated molecular pattern (PAMP) commonly formed during the ...

Discovery opens up new RNA therapies for diseases driven by auto ...

RNA therapeutics can modulate our immune system's response. · Research into how this operates has so far focused on how to stop immune responses, ...

RNA Silencing - an overview | ScienceDirect Topics

Clues of its existence came ... immune system that recognizes and cleaves the invading RNA. Virus-induced RNA silencing is triggered by double-stranded RNA ...

Our own RNA triggers an immune response to viral infections

The RNA molecules bind to these receptors, triggering defense mechanisms in the innate immune system to tackle the infection. It was previously believed that ...

Researchers Discover First Immune Stimulating Long Noncoding ...

Researchers Discover First Immune Stimulating Long Noncoding RNA Involved in Body's Response to Cancer ... New Clues to Classic Cancer ...

In brief: Tweaking RNA protects cells from harmful inflammation

These cells appear to confuse their own RNA for the genetic material of viruses, a mistake that can make them send out false infection alarms.

Inflammatory trigger a new clue in Alzheimer's

“These double-stranded RNAs look like a virus to the immune system even though the jumping genes are a part of our normal genome.” The ...

RNA viruses and the cGAS-STING pathway - ScienceDirect.com

The past decade has provided critical information about the cytoplasmic innate immune sensing pathway of cyclic GMP-AMP synthase (cGAS) and ...

Shaping the Innate Immune Response Through Post-Transcriptional ...

Foreign RNAs can display specific features that distinguish them from endogenous RNAs and allow them to trigger an immune response through sensing by PRRs.

RNA2Immune: A Manually Curated Database of Experimentally ...

The immune system is extremely complex and versatile, simultaneously recognizing and responding to pathogens, maintaining organ homeostasis, and ...

Innate immune evasion strategies of SARS-CoV-2 - Nature

With the aid of nuclear transport receptors (importins), cellular transcription factors that are induced in response to infection translocate ...

RNAs Containing Modified Nucleotides Fail To Trigger RIG-I ...

While the presence of nucleotide modifications in RNA is known to correlate with diminished innate immune signaling, the underlying mechanisms ...

New algorithm could help investigate the genetic clues behind ...

When a pathogen enters a healthy organism, it triggers an immune response that includes recombination of the germline genes and their random ...

A putative RNA-interference-based immune system in prokaryotes

... finding are that, even among closely related prokaryotes, the ... Fire A: RNA-triggered gene silencing. Trends Genet 1999,15(9):358 ...

Schlafen 11 triggers innate immune responses through its ... - Science

Nucleic acids are major structures detected by the innate immune system. Although intracellular single-stranded DNA (ssDNA) accumulates during ...

Innate immune modulation by RNA viruses: emerging insights from ...

HCV is one example of a virus that has devised a means to block the initial triggering of the host innate immune response. Several studies have shown that the ...

From mRNA sensing to vaccines: Immunity - Cell Press

Too little stimulation of the innate immune system by RNA and there is no adaptive immune response, akin to giving antigen without adjuvant. Too ...