Selective Inhibition of Endoplasmic Reticulum|associated ...

Selective inhibition of endoplasmic reticulum-associated ... - PubMed

Endoplasmic reticulum (ER)-associated degradation (ERAD) is the major quality control pathway of the cell. The most common disease-causing protein folding ...

Selective Inhibition of Endoplasmic Reticulum-associated ...

We hypothesize that selective inhibition of ERAD not only rescues ΔF508-CFTR, but also suppresses interleukin (IL)-8 levels, the major inflammatory cytokine in ...

Discovery of Selective Inhibitors of Endoplasmic Reticulum ...

ERAP1 is an endoplasmic reticulum-resident zinc aminopeptidase that plays an important role in the immune system by trimming peptides for ...

Endoplasmic reticulum stress: molecular mechanism and ... - Nature

Therefore, inhibition of PTM results in protein accumulation and ER stress in TM cells, which causes TM cell loss and ECM accumulation.

Inhibition of Endoplasmic Reticulum Associated Degradation ...

Here we investigate UPR induction if the other major proteolytic pathway of the ER -ER associated degradation (ERAD)- is inhibited. Surprisingly, impairment of ...

(PDF) Selective inhibition of endoplasmic reticulum-associated ...

We conclude that VCP is an integral component of ERAD and cellular stress pathways induced by the unfolded protein response and may be central ...

Chemical Chaperones to inhibit Endoplasmic reticulum stress | DDDT

Note that Vildagliptin (7), a marketed anti-diabetic drug and DPP-4 inhibitor, showed chaperone activity to reduce ER stress. Miyake et al ...

Pharmacological induction of selective endoplasmic reticulum ...

We report that ER stress combined with ISR inhibition causes an impaired maturation of several tyrosine kinase receptors (RTKs), consistent with a partial ...

(PDF) Selective Inhibition of Endoplasmic Reticulum-associated ...

We conclude that VCP is an integral component of ERAD and cellular stress pathways induced by the unfolded protein response and may be central ...

ToP-DNJ, a Selective Inhibitor of Endoplasmic Reticulum α ...

Abstract ... Iminosugars have therapeutic potential against a range of diseases, due to their efficacy as glycosidase inhibitors. A major ...

Inhibition of protein translocation at the endoplasmic reticulum ...

The mechanisms through which ESI induces ER stress are not known, although inhibition of ERAD and/or perturbation of ubiquitin homoeostasis ...

A guide to assessing endoplasmic reticulum homeostasis and stress ...

In particular, transcription factor such as ATF4 is selectively induced in response to eIF2α phosphorylation [19, 20]. ATF4 acts as a ...

Endoplasmic-reticulum stress pathway-associated mechanisms of ...

Avoid common mistakes on your manuscript. Introduction. After the approval of proteasome inhibitor, bortezomib (BTZ), in the ...

Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer ...

Selective Vulnerability of Cancer Cells by Inhibition of Ca2+ Transfer from Endoplasmic Reticulum to Mitochondria. César Cárdenas. César ...

Pharmacological inhibition of cystine–glutamate exchange induces ...

The upregulation of the ER stress response gene CHAC1 (ChaC, cation transport regulator homolog 1) serves as a useful pharmacodynamic marker of ...

Overexpression of endoplasmic reticulum-resident chaperone ...

Proteasome inhibitors are a novel class of anticancer agents that induce tumour cell death via endoplasmic reticulum (ER) stress.

Endoplasmic Reticulum Quality Control in Immune Cells - Frontiers

The major protein degradation system includes the ubiquitin-proteasome system (UPS) and the autophagic-lysosomal system (ALS), which can selectively degrade ...

Potential Role for Protein Kinases in Regulation of Bidirectional ...

Recent evidence suggests a regulatory connection between cell volume, endoplasmic reticulum (ER) export, and stimulated Golgi-to-ER transport.

A Principal Role for the Proteasome in Endoplasmic Reticulum ...

), who reported recently that selective peptidyl-glutamyl hydrolyzing inhibition is insufficient to inhibit protein degradation in vivo. These data all ...

Selective inhibition of protein secretion by abrogating receptor–coat ...

We map the protein–protein interaction network that drives secretion via the endoplasmic reticulum (ER) export receptor SURF4. We show that interaction with the ...