Senescence and apoptosis

Senescence and apoptosis: dueling or complementary cell fates?

Here, we discuss the advantages that the senescence program may have over apoptosis as a tumor protective mechanism, as well as non‐neoplastic functions.

Senescence and apoptosis: dueling or complementary cell fates?

Here, we discuss the advantages that the senescence program may have over apoptosis as a tumor protective mechanism, as well as non-neoplastic functions.

Synopsis on cellular senescence and apoptosis

As described, the hallmark of cellular senescence is the loss of proliferative capacity, whereas the hallmark of apoptosis is sequential cellular events that ...

Lack of apoptosis leads to cellular senescence and tumorigenesis in ...

We have studied the consequences of subjecting Drosophila epithelial cells defective in apoptosis to stress or genetic perturbations that normally cause ...

Senescence and Apoptosis: Architects of Mammalian Development

In this review, we focus on apoptosis and senescence; the former as an integral mechanism that plays a critical role not only in mature organisms.

Apoptotic stress causes mtDNA release during senescence ... - Nature

Our results reveal that apoptosis and senescence are regulated by similar mitochondria-dependent mechanisms and that sublethal mitochondrial ...

Targeted Apoptosis of Senescent Cells Restores Tissue ...

Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging.

Bcl-2 family proteins as targets for cancer therapy - ScienceDirect

Cell death by apoptosis and permanent cell cycle arrest by senescence serve as barriers to the development of cancer. Chemotherapeutic agents not only ...

Early SRC activation skews cell fate from apoptosis to senescence

We propose that inhibiting SRC could be exploited to favor apoptosis over senescence in tissues to improve health outcomes.

Apoptosis or senescence? Which exit route do epithelial cells and ...

We propose that, upon stress insults, human fibroblasts seem to predominantly respond via senescence, while epithelial cells prefer to exert apoptosis.

Cell death and senescence | Journal of Translational Medicine

This process, which has been dubbed cellular senescence, resembles RCD in that it can also be elicited by perturbations of intracellular or ...

Special Issue “Role of Apoptosis and Cellular Senescence in ... - MDPI

In the early and reproductive stages of life, apoptosis and cellular senescence function as the main mechanisms of tumor suppression, providing an effective ...

What is the connection between senescence and apoptosis? - Socratic

They are both mechanisms of damaged cells to avoid replication. Apoptosis is the process in which a cell decides to kill itself. Senescence ...

Apoptosis resistance of senescent cells is an intrinsic barrier for ...

We revealed that apoptosis resistance, previously recognized as a common characteristic of senescence, in fact, is not a general feature of ...

Senescence, Apoptosis or Autophagy? - Karger Publishers

In tumour cell lines exposed to cytotoxic drugs, autophagic cell death reportedly avoids apoptosis as well as cellular senescence [45, 46] .

[PDF] Senescence, Apoptosis or Autophagy? - Semantic Scholar

The molecular networks that allow damaged cells either to adapt to stress or to engage in programmed-cell-death pathways are summarized.

Roles of Apoptosis and Cellular Senescence in Cancer and Aging

Apoptosis and senescence are two types of cellular response to damages that are altered in both cancer and aging, albeit through different mechanisms.

Senescence and apoptosis: Dueling or complementary cell fates?

Abstract. In response to a variety of stresses, mammalian cells undergo a persistent proliferative arrest known as cellular senescence. Many ...

Role of Apoptosis and Cellular Senescence in Cancer and Aging

This article belongs to the Special Issue Role of Apoptosis and Cellular Senescence in Cancer and Aging

Senescence, apoptosis, and stem cell biology: the rationale for an ...

It is clear, however, that in abnormal cells, p53 can induce transient cell-cycle arrest, permanent arrest (senescence), or apoptosis, depending on the context ...