- Shaping DNA damage responses🔍
- Therapeutic potential of targeting telomeric proteins and DNA repair ...🔍
- Alterations of DNA damage response pathway🔍
- A new wave of innovations within the DNA damage response🔍
- The ATM|mediated DNA|damage response🔍
- Subset|specific mitochondrial stress and DNA damage shape T cell ...🔍
- DNA damage response signaling pathways and targets for ...🔍
- Key molecular DNA damage responses of human cells to radiation🔍
Shaping DNA damage responses
Shaping DNA damage responses: Therapeutic potential of targeting ...
Targeting DDR machinery is a promising strategy to increase the sensitivity of cancer cells to existing cancer therapies.
Therapeutic potential of targeting telomeric proteins and DNA repair ...
Shaping DNA damage responses: Therapeutic potential of targeting telomeric proteins and DNA repair factors in cancer · Abstract · Publication types · MeSH terms.
Alterations of DNA damage response pathway: Biomarker and ...
Therefore, DNA repair is crucial for maintaining genome stability. Multiple mechanisms involve DNA damage response (DDR) system: direct repair (DR), base ...
Therapeutic potential of targeting telomeric proteins and DNA repair ...
Shaping DNA damage responses: Therapeutic potential of targeting telomeric proteins and DNA repair factors in cancer · Abstract · Introduction · Section snippets.
A new wave of innovations within the DNA damage response - Nature
DNA damage response (DDR) network is responsible for maintenance of genome integrity in cells. As cancer cells frequently carry DDR gene ...
The ATM-mediated DNA-damage response: taking shape - Cell Press
Our understanding of the DNA-damage response has evolved: whereas previously the focus was on DNA repair, we now appreciate that the response to DNA lesions ...
Subset-specific mitochondrial stress and DNA damage shape T cell ...
In this case, p53 and STING play broad and likely frequent roles in genome maintenance to mitigate inflammation-induced DNA damage. MATERIALS ...
DNA damage response signaling pathways and targets for ... - Nature
As a signal, DNA damage activates a series of biochemical reactions in response to IR insult, triggering a variety of cellular responses.
Key molecular DNA damage responses of human cells to radiation
Novel responses of DNA damage have been emerging, for example, cancer cells have developed a strategy to keep alive under irradiation, by increasing DNA breaks ...
ATM, DNA-PKcs and ATR: shaping development through the ...
Genomic integrity is critical for normal development, healthy aging and suppressing oncogenic transformation. The DNA damage response (DDR) ...
Beyond the Trinity of ATM, ATR, and DNA-PK: Multiple Kinases ...
Beyond the Trinity of ATM, ATR, and DNA-PK: Multiple Kinases Shape the DNA Damage Response in Concert With RNA Metabolism ... Our genome is constantly exposed to ...
A multi-scale map of protein assemblies in the DNA damage response
The DNA damage response (DDR) ensures error-free DNA replication and transcription and is disrupted in numerous diseases.
DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome.
Accolades for the DNA Damage Response
Further work identified an upstream kinase, which controls cell-cycle progression and DNA damage–induced transcription. Elledge's work in yeast thus established ...
DNA damage responses and p53 in the aging process | Blood
Mutations in the BRCA1 and BRCA2 genes predispose to breast and ovarian cancer and are both involved in HR. Interestingly, despite the backup DSB repair ...
DNA Damage Response and Immune Defense - MDPI
DNA damage is the cause of numerous human pathologies including cancer, premature aging, and chronic inflammatory conditions. The DNA damage response (DDR), ...
The DNA damage response links human squamous proliferation ...
The results altogether show that the DDR is required to maintain the balance proliferation differentiation and suggest that is part of the ...
When DNA-damage responses meet innate and adaptive immunity
DNA-Damage Response (DDR) networks are complex signaling pathways used by multicellular organisms to prevent DNA damage. Depending on the type ...
DNA damage (naturally occurring) - Wikipedia
The DNA damage response (DDR) is a complex signal transduction pathway which recognizes when DNA is damaged and initiates the cellular response to the damage.
DNA Damage Response (DDR) landscape of endometrial cancer ...
Genome maintenance is an enabling characteristic that allows neoplastic cells to tolerate the inherent stresses of tumorigenesis and evade therapy-induced ...