Short telomeres correlate with a strong induction of cellular ...

In this study, we investigated two different DFC lines with one cell line inducing cellular senescence faster. Our results showed that short ...

Our results supported our initial hypothesis that telomere length and genomic instability correlate with the accelerated induction of ...

(PDF) Short telomeres correlate with a strong induction of cellular ...

We hypothesized that short telomere length and increased DNA damage with genomic instability correlate with the accelerated induction of cellular senescence.

Short telomeres correlate with a strong induction of cellular ...

The results supported the initial hypothesis that telomere length and genomic instability correlate with the accelerated induction of cellular senescence in ...

The Length of the Shortest Telomere as the Major Determinant of the ...

In the absence of this enzyme, the progressive shortening of telomeres ultimately leads to a cell-cycle arrest, a pathway called senescence. One major function ...

Short telomeres correlate with a strong induction of cellular ... - Gale

A number of studies have shown that telomere length and the response to DNA damage are responsible for the induction of cellular senescence [9-13]. The telomere ...

Telomeres and Cell Senescence - Size Matters Not - ScienceDirect

Since persistent telomeric DNA damage is a feature of replicative, stress- and oncogene-induced senescence, it has been suggested that unrepaired telomeres ...

Additional file 2: of Short telomeres correlate with a strong induction ...

Figure S2. Western Blot Analyses of DFC_F and DFC_S in cell passages before and after induction of cellular senescence to control Real-Time RT PCR array ...

Short telomeres correlate with a strong induction of cellular ... - CoLab

We hypothesized that short telomere length and increased DNA damage with genomic instability correlate with the accelerated induction of cellular senescence.

Telomere dysfunction in ageing and age-related diseases - Nature

VSMCs in human atherosclerotic plaques show cellular senescence markers and telomeres that are markedly shorter than those in unaffected vessels ...

Markers of cellular senescence. Telomere shortening as ... - Aging-US

With each replication, telomeres are shortened due to the inability of DNA-polymerase to work on single-stranded 3′ ends. This mechanism of replication and ...

Accelerated telomere shortening in response to life stress - PNAS

Recent research points to the crucial roles of telomeres and telomerase in cellular aging and potentially in disease. Telomeres are DNA–protein complexes that ...

Telomere Length as a Marker of Biological Age - Frontiers

Telomere shortening is a well-known hallmark of both cellular senescence and organismal aging. An accelerated rate of telomere attrition is also a common ...

Stress and telomere shortening: Insights from cellular mechanisms

Critically short telomeres or the collapse of the telomere structure caused by displacement of telomere binding protein complex shelterin elicit a DNA damage ...

Heart-Breaking Telomeres | Circulation Research - AHA Journals

Shortened telomeres also lead to stem cell dysfunction impairing their capacity to self-renew and mobilization to repair tissue damage, which in ...

Association Between Telomere Length and Experimentally Induced ...

Results Rates of infections and clinical illness were 69% (n = 105) and 22% (n = 33), respectively. ... CD8CD28− was the only cell population in which shorter ...

Telomere shortening rate predicts species life span - PNAS

Telomere shortening to a critical length can trigger aging and shorter life spans in mice and humans by a mechanism that involves induction of a ...

Genetic, parental and lifestyle factors influence telomere length

The higher genetic contribution to naïve T-cell telomere length that we observe might be explained by the fact that these cells reflect less ...

Physical activity and telomere length: Impact of aging and potential ...

Over time, telomere length decreases until the telomere becomes too short for the cell to divide, resulting in cellular senescence. This ...

Shorter telomere lengths in patients with severe COVID-19 disease

The SARS-CoV-2 virus infects many different cell types, forcing cell turn-over and regeneration to maintain tissue homeostasis. We hypothesize ...