Sickle Cell Disease Backgrounder
What Is Sickle Cell Disease? | NHLBI, NIH
In sickle cell disease, red blood cells are misshaped, typically crescent- or “sickle”-shaped due to a gene mutation that affects the hemoglobin ...
History of Sickle Cell Disease - Red Cross Blood Donation
Origins ... Research shows that the mutation causing sickle cell disease arose in Africa thousands of years ago to help protect against malaria, a historically ...
Sickle Cell Disease | Johns Hopkins Medicine
Sickle cell disease (SCD) is an inherited blood disorder. That means it is passed down from a parent's genes. It causes the body to make abnormal hemoglobin.
About Sickle Cell Disease - CDC
SCD is a genetic condition that is present at birth. It is inherited when a child receives two genes—one from each parent—that code for abnormal ...
Sickle Cell Disease Backgrounder - Novartis
Overview of sickle cell disease, including causes, symptoms, diagnosis and treatment, and chronic iron overload due to blood transfusions.
Sickle Cell Disease - Hematology.org
Healthy red blood cells are flexible so that they can move through the smallest blood vessels. In sickle cell disease, the hemoglobin is abnormal, causing the ...
The Natural History of Sickle Cell Disease - PMC - PubMed Central
The term sickle cell disease embraces a group of genetic conditions in which pathology results from the inheritance of the sickle cell gene.
Sickle Cell Disease (SCD): Practice Essentials, Background, Genetics
Sickle cell disease (SCD) and its variants are genetic disorders resulting from the presence of a mutated form of hemoglobin, hemoglobin S ...
History and Evolution of Sickle Cell Disease
A person has sickle cell trait when they inherit one copy of an abnormal (sickle) HBB gene and one copy of a normal HBB gene.
Sickle Cell Disease: Understanding its History, Symptoms ...
The sickle cell mutation first happened generations ago to protect people against malaria, which is a serious and life-threatening infection ...
History & Timeline of SCD — Sickle Cell Foundation of Minnesota
Discovery of Sickle Cell Disease in the US ... “Peculiar elongated and sickle-shaped” is how sickle cells were first described in 1904 by intern Ernest Edward ...
The most serious type is called sickle cell anaemia. Sickle cell disease is particularly common in people with an African or Caribbean family background. People ...
History of Sickle Cell Disease
Recorded History in the United States ... The first case of sickle cell disease (SCD) in the United States was described in 1904 when Walter ...
Sickle-Cell Disease History - News-Medical
The first time that the disease was referenced in literature was in 1910. There were several case reports that followed this, as well as public awareness and ...
Sickle Cell Disease - National Human Genome Research Institute
Sickle cell disease is a hereditary disease seen most often among people of African ancestry. Caused by mutations in one of the genes that encode the ...
Sickle Cell Disease (SCD) Clinical Presentation
Sickle cell disease (SCD) usually manifests early in childhood. For the first 6 months of life, infants are protected largely by elevated ...
Sickle-Cell Disease - an overview | ScienceDirect Topics
Sickle cell disease (SCD) is a term given for a group of inherited red blood cell disorders that is caused by an abnormal hemoglobin, called hemoglobin S or ...
These independent events occurred between 3,000 and 6,000 generations ago, approximately 70-150,000 years. A significant figure in Sickle Cell history is Dr.
The thorny history of sickle cell anemia - JHU Hub
Johns Hopkins researchers look inward at the past, present, and future of treatment for this disease.
Sickle cell disease: MedlinePlus Genetics
Sickle cell disease is a group of disorders that affects hemoglobin, the molecule in red blood cells that delivers oxygen to cells throughout the body.