Signaling at the inhibitory natural killer cell immune synapse ...

Negative signals are transmitted by NK inhibitory receptors (killer immunoglobulin-like receptors, KIR) at the site of membrane apposition ...

Signaling at the inhibitory natural killer cell immune synapse ... - PNAS

Natural killer (NK) cell cytotoxicity is determined by a balance of positive and negative signals. Negative signals are transmitted by NK inhibitory ...

Signaling at the inhibitory natural killer cell immune synapse ... - PNAS

Natural killer (NK) cell cytotoxicity is determined by a balance of positive and negative signals. Negative signals are transmitted by.

Controlling NK Cell Responses: Integration of Signals for Activation ...

Natural killer (NK) cells are lymphocytes that function at the interface between innate and adaptive immunity. NK cells contribute directly to immune defense ...

Illuminating the dynamics of signal integration in Natural Killer cells

Natural Killer (NK) cell responses are shaped by the integration of signals transduced from multiple activating and inhibitory receptors at ...

Termination of the Activating NK Cell Immunological Synapse Is an ...

... natural killer cell activation and inhibition ... signaling pathways and cortical cytoskeleton in cytolytic and noncytolytic natural killer cell immune synapses.

The Molecular Mechanism of Natural Killer Cells Function and Its ...

Natural killer (NK) cells are innate immune cells that show strong ... Schematic representation of natural killer (NK) cell inhibitory receptor signaling.

Natural Killer Cell Signal Integration Balances Synapse Symmetry ...

Natural killer (NK) cells discern the health of other cells by recognising the balance of activating and inhibitory ligands expressed by each target cell.

Natural killer cell cytotoxicity and its regulation by inhibitory receptors

Natural killer (NK) cells utilize an array of germ-line encoded activating and inhibitory receptors to sense their surroundings. The signals ...

Microclusters of inhibitory killer immunoglobulin–like receptor ...

Natural killer (NK) cell activation is regulated by a balance between activating and inhibitory cell surface receptors (Vivier et al., 2004; ...

Natural killer cell immune synapse formation and cytotoxicity are ...

Natural killer (NK) cells use a variety of germline-encoded activating and inhibitory receptors to detect signs of disease in other cells. If the balance of ...

Signal transduction in natural killer cells. - Semantic Scholar

Natural killer cells and cancer: Regulation by the killer cell Ig-like receptors (KIR) · Inhibitory Ly49 receptors on mouse natural killer cells. · Chapter 3 NK ...

SHP-1 localization to the activating immune synapse promotes NK ...

Natural killer (NK) cells recognize virally infected cells and tumors. NK cell function depends on balanced signaling from activating ...

Immunological synapse - Wikipedia

Inhibitory immunological synapse of NK cells. When an NK cell ... "The human natural killer cell immune synapse". Proc Natl Acad Sci U S A. 96 ...

Inhibitory signaling blocks activating receptor clustering and induces ...

Natural killer (NK) lymphocytes use a variety of activating receptors to recognize and kill infected or tumorigenic cells during an innate ...

A Peptide Antagonist Disrupts NK Cell Inhibitory Synapse Formation

Thus, peptide antagonism of NK cells is an active phenomenon of inhibitory synapse disruption. Introduction. Natural killer cells are an important component of ...

NK cell survival mediated through the regulatory synapse with ... - JCI

Survival and inhibition signals were enriched at the immune synapse during NK cell and mDC interactions. (A) Conjugates were formed, fixed, and ...

Inhibitory Receptor Signaling Destabilizes Immunological Synapse ...

... natural killer (NK) cell tolerance toward normal, healthy tissue. A number of studies, mostly using immortalized NK cell lines, have ...

Inhibitory receptor signaling destabilizes immunological synapse ...

In this manner, ITIM-coupled receptors play a crucial role in maintaining natural killer (NK) cell tolerance toward normal, healthy tissue. A.

The Lytic NK Cell Immunological Synapse and Sequential Steps in ...

Natural killer (NK) cells are lymphocytes of the innate immune system that are critical in host defense. They are best known for their ability to mediate ...