Single|cell analysis of the earliest cell fate decisions in development

Single-cell analysis of the earliest cell fate decisions in development

The findings propose how embryonic cells may be deviated away from a default cell state and awoken to new developmental possibilities during ...

Single-cell analysis of the earliest cell fate decisions in development

Researchers at the Babraham Institute, EMBL's European Bioinformatics Institute (EMBL-EBI), CRUK Cambridge Institute and the Wellcome – MRC ...

Single-cell transcriptional analysis to uncover regulatory circuits ...

Single-cell transcriptional analysis to uncover regulatory circuits driving cell fate decisions in early mouse development. Bioinformatics ...

Resolution of Cell Fate Decisions Revealed by Single-Cell Gene ...

... earliest cell fate decisions of the developing mouse embryo. Results. Identification of Candidate Transcription Factors for Single-Cell Analysis.

Single-cell transcriptional analysis to uncover regulatory circuits ...

Abstract. Motivation: Transcriptional regulatory networks controlling cell fate decisions in mammalian embryonic development remain elusive despite a long.

Early cell fate decisions in the mouse embryo - PubMed

During mammalian preimplantation development, the fertilised egg gives rise to a group of pluripotent embryonic cells, the epiblast, ...

scRNA-sequencing in chick suggests a probabilistic model for cell ...

... earliest cell fate decisions in the ectoderm of chicken embryos. The evidence is solid, and the authors mostly succeed in presenting their ...

Using single‐cell genomics to understand developmental processes ...

... cells in mouse embryos defines cell fate choices in early development. Observing heterogeneity in cultured cells. Embryonic stem cells are a ...

Omics Views of Mechanisms for Cell Fate Determination in Early ...

These cellular heterogeneities affect the first cell fate decision in mouse preimplantation development ... early mouse development by a single-cell Hi-C analysis.

Cell fate decision by a morphogen-transcription factor-chromatin ...

We provide here an in vitro model system to analyze early cell fate decisions in development, the choice to becoming epiblast- or hypoblast- ...

Single-cell multi-omics and lineage tracing to dissect cell fate ...

Summary and conclusions. Cell fate decisions are central to development, homeostasis, and adaptive responses to sustain the cellular ...

Single-cell analysis of cell fate bifurcation in the chordate Ciona

Many early cell fate decisions in the early Ciona embryo ... Ciona development is unusual in that a large number of cell fate decisions ...

A single-cell snapshot of cell-fate decisions

early embryonic cells make cell-fate decisions toward the ME and DE lineages. In-depth analysis of these data could also help to develop efficient ...

Cell fate decisions and axis determination in the early mouse embryo

The mouse embryo generates multiple cell lineages, as well as its future body axes in the early phase of its development. The early cell ...

Revealing Dynamic Mechanisms of Cell Fate Decisions From Single ...

It first constructs a data-driven “quantitative” (i.e., each cell is endowed with spatiotemporal information) developmental landscape, which provides a global ...

Predicting Cell Fate Decisions Using Single-Cell Analysis and the ...

ISB researchers developed a new theory to exploit burgeoning single-cell molecular profiling measurements to make predictions of future cell behaviors.

Deciphering driver regulators of cell fate decisions from single-cell ...

Single-cell technologies enable the dynamic analyses of cell fate mapping. However, capturing the gene regulatory relationships and ...

A single-cell snapshot of cell-fate decisions

... developed techniques, single-cell RNA sequencing ... ∙ Zeng, Y. ∙ Fang, Z. ... Single-cell analysis reveals lineage segregation in early post- ...

Spatiotemporal structure of cell fate decisions in murine neural crest

Neural crest cells are embryonic progenitors that generate numerous cell types in vertebrates. With single-cell analysis, we show that mouse ...

Early cell fate decisions in the mouse embryo in - Reproduction

During mammalian preimplantation development, the fertilised egg gives rise to a group of pluripotent embryonic cells, the epiblast, and to the ...