Single‐cell analyses to reveal hematopoietic stem cell fate decisions

Single-cell analyses to reveal hematopoietic stem cell fate decisions

Hematopoietic stem cells (HSCs) are the best studied adult stem cells with enormous clinical value. Most of our knowledge about their biology relies on ...

This Review will focus on current attempts to investigate individual HSCs at molecular and functional levels.

Single-cell analyses to reveal hematopoietic stem cell fate decisions

Hematopoietic stem cells (HSCs) are the best studied adult stem cells with enormous clinical value. Most of our knowledge about their biology relies on.

Single-cell transcriptomics reveal the dynamic of haematopoietic ...

Our analysis identified the genes and transcription factor networks activated during the endothelial-to-haematopoietic switch and IAHC cell ...

Single-cell gene and isoform expression analysis reveals signatures ...

Single-cell approaches have revealed that the haematopoietic hierarchy is a continuum of differentiation, from stem cell to committed ...

Single cell analyses to reveal hematopoietic stem cell fate decisions ...

Request PDF | Single cell analyses to reveal hematopoietic stem cell fate decisions | Hematopoietic stem cells (HSCs) are the best studied adult stem cells ...

Single‐cell analyses to reveal hematopoietic stem cell fate decisions

Hematopoietic stem cells (HSCs) are the best studied adult stem cells with enormous clinical value. Most of our knowledge about their biology relies on ...

and single-cell-resolved model of murine bone marrow hematopoiesis

Transplanted stem cells show strong acceleration of differentiation at specific stages of erythroid and neutrophil production, illustrating how ...

Single-cell analyses and machine learning define hematopoietic ...

An interactive data set of single-cell RNA and CITE sequencing of human HSPCs derived from pluripotent stem cells has been generated. An ...

A comprehensive single cell transcriptional landscape of human ...

Hematopoietic Stem/Progenitor cells (HSPCs) are endowed with the role of maintaining a diverse pool of blood cells throughout the human life ...

Resolving Fates and Single-Cell Transcriptomes of Hematopoietic ...

Lineage tracing reveals hematopoietic stem cell (HSC) fates, while single-cell RNA sequencing identifies snapshots of HSC transcriptomes.

Single-cell RNA-seq reveals a concomitant delay in differentiation ...

Hematopoietic stem cells (HSCs) are the guarantor of the proper functioning of hematopoiesis due to their incredible diversity of potential.

Systematic single-cell analysis reveals dynamic control of ...

Our study provides a systematic vision of how TEs are dynamically controlled to promote the hematopoietic fate decisions through transcriptional and cis- ...

Defining the Emerging Blood System During Development at Single ...

The well-characterized, gradual maturation of hematopoietic stem cells (HSCs) into functional blood and immune cells serves as a conceptual model for stem-cell- ...

Single-cell multi-omics and lineage tracing to dissect cell fate ...

Understanding, predicting, and manipulating cell fate has been a long-sought goal of developmental and regenerative biology. Recent insights ...

Single-Cell Proteomics Reveal that Quantitative Changes in Co ...

Hematopoiesis provides an accessible system for studying the principles underlying cell-fate decisions in stem cells. Proposed models of ...

A single-cell resolution map of mouse hematopoietic stem and ...

Because cell fate choices are executed at the individual cell level, new single-cell profiling technologies offer exciting possibilities for ...

Single-Cell RNA Sequencing to Disentangle the Blood System

Single-cell analysis has been used to identify rare cell types in heterogeneous populations, such as hematopoietic stem cell–like cells in ...

Single-cell sequencing delivers hematopoietic stem cell specification

This study provides a paradigm to delineate cell fate decision mechanisms on cells with elusive heterogeneity. Stem cells hold great promise for ...

Single cell transcriptomics reveals unanticipated features of early ...

Molecular changes underlying stem cell differentiation are of fundamental interest. scRNA-seq on murine hematopoietic stem cells (HSC) and their progeny MPP1 ...