Small|Molecule Antibiotic Drug Development

Small-Molecule Antibiotic Drug Development: Need and Challenges

Small-molecule antibiotics remain essential and irreplaceable tools for fighting infections, and efforts to develop novel and improved versions deserve ongoing ...

Antibiotics in the clinical pipeline as of December 2022 - Nature

The need for new antibacterial drugs to treat the increasing global prevalence of drug-resistant bacterial infections has clearly attracted ...

New small molecule found to suppress the evolution of antibiotic ...

Researchers from the University of Oxford have developed a new small molecule that can suppress the evolution of antibiotic resistance in ...

A small molecule that inhibits the evolution of antibiotic resistance

Hundreds of drug-resistant bacterial strains continue to emerge and are currently responsible for 1.3 million deaths every year, with a projection of >10 ...

New molecule found to suppress bacterial antibiotic resistance ...

Researchers from the University of Oxford have developed a new small molecule ... compounds as 'anti-evolution' drugs to combat antibiotic ...

Towards the sustainable discovery and development of new antibiotics

In fact, only a small fraction of the antibiotics approved over the past 40 years represents new compound classes, while the majority were ...

Special Issue : Small-Molecule Antibiotic Drug Development - MDPI

In this Special Issue, we are looking for all kinds of articles regarding the development of antibiotics based on small molecules. From the synthetic to the ...

Generative AI develops potential new drugs for antibiotic-resistant ...

A new model, dubbed SyntheMol (for synthesizing molecules), created structures and chemical recipes for six novel drugs aimed at killing resistant strains of ...

Paving the Way for a New Class of Antibiotics

Revealing the inner workings of drug-resistant bacteria is informing development of much-needed new antibiotics. ... molecule itself. The ...

New small molecule offers hope in combating antibiotic resistance

Researchers from the University of Oxford have developed a new small molecule that can suppress the evolution of antibiotic resistance in bacteria.

Few antibiotics under development – How did we end up here?

Since then there has been a lack of innovation in the field, and today there are few novel antibiotic classes in the drug pipeline[10]; [11]; [2]. The ...

2023 Antibacterial agents in clinical and preclinical development

The analysis covers traditional (direct-acting small molecules) and non-traditional antibacterial agents in development worldwide. It evaluates ...

Researchers develop molecules for a new class of antibiotics that ...

In contrast, the Bazan Lab has developed COEs to be highly selective for bacteria. In Chemical Communications, Moreland and team investigated ...

New antibiotic uses novel method to target deadly drug-resistant ...

“Drug discovery that targets harmful Gram-negative bacteria is a long-standing challenge owing to difficulties in getting molecules to cross the ...

Tracking the Global Pipeline of Antibiotics in Development, March ...

Approximately 1 in 4 drugs in the pipeline represent a novel drug class or mechanism of action. None of these are potentially active against ...

High-throughput screening of small-molecules libraries identified ...

There are few antibiotics in clinical development and the last broad-spectrum drug, cefidericol, was approved by the U.S. Food and Drug Administration (FDA) in ...

Lack of innovation set to undermine antibiotic performance and ...

... development (R&D) efforts to address the discovery void in antibacterial drug development ... antibiotics is driven by small- and medium ...

Challenges and opportunities in the discovery, development, and ...

The manufacturing of effective antibiotic products is often faced with unique challenges not typically seen in small-molecule pharmaceutical development.

The Science of Antibiotic Discovery - Cell Press

Traditional methods of screening environmental isolates or compound libraries have not produced a new drug in over 30 years. Antibiotic ...

Artificial intelligence yields new antibiotic | MIT News

Once the model was trained, the researchers tested it on the Broad Institute's Drug Repurposing Hub, a library of about 6,000 compounds. The ...