Small|Molecule Inhibitors of the SOX18 Transcription Factor.

Small-Molecule Inhibitors of the SOX18 Transcription Factor - PubMed

Pharmacological modulation of transcription factors (TFs) has only met little success over the past four decades.

Article Small-Molecule Inhibitors of the SOX18 Transcription Factor

SAR for SOX18-DNA Binding Inhibition. Activity data display some clear SAR for SOX18-DNA binding inhibition, with a reduction or elimination of activity by any ...

Small-Molecule Inhibitors of the SOX18 Transcription Factor

As a key molecular switch for driving angiogenesis and lymphangiogenesis during development, the transcription factor SOX18 is a potential molecular target for ...

Targeting SOX18 Transcription Factor Activity by Small-Molecule ...

The transcription factor SOX18 has been shown to play a crucial role in lung cancer progression and metastasis.

Small-Molecule Inhibitors of the SOX18 Transcription Factor

This approach shows that the inhibitors block transcriptional activation by disrupting protein-protein interaction. Fontaine et al., 2017, Cell Chemical Biology ...

R-propranolol is a small molecule inhibitor of the SOX18 ... - eLife

Identification of the R(+)-propranolol enantiomer as an inhibitor of the SOX18 transcription factor activity breaks open potential of drug ...

Small-Molecule Inhibitors of the SOX18 Transcription Factor

Genome-wide analysis of SOX18 binding locations on the chromatin revealed enrichment for a SOX dimer binding motif, correlating with genes with a strong ...

R-propranolol is a small molecule inhibitor of the SOX18 ...

R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma · NOTES · Abstract.

Small-Molecule Inhibitors of the SOX18 Transcription Factor.

We identified two compounds, which inspired a series of synthetic SOX18 inhibitors, able to interfere with the SOX18 HMG DNA-binding domain, and to disrupt HMG- ...

Transcription Factor SOX18 Promotes Clear Cell Renal Cell ...

Importantly, Overman and colleagues demonstrated that targeting SOX18 with a small-molecule inhibitor was an effective approach to treat breast cancer in mice ( ...

Small-molecule inhibitors of the SOX18 transcription factor - UQ ...

Pharmacological modulation of transcription factors (TFs) has only met little success over the past four decades.

Small-Molecule Inhibitors of the SOX18 Transcription Factor ...

Semantic Scholar extracted view of "Small-Molecule Inhibitors of the SOX18 Transcription Factor." by F. Fontaine et al.

Small-Molecule Inhibitors of the SOX18 Transcription Factor. | Sigma ...

Small-Molecule Inhibitors of the SOX18 Transcription Factor. by Frank Fontaine, Jeroen Overman, Mehdi Moustaqil, Sreeman Mamidyala, Angela Salim, ...

Pharmacological targeting of the transcription factor SOX18 delays ...

We describe a small-molecule that is able to disrupt a discrete subset of SOX18-dependent interactions. This compound selectively suppressed ...

An endothelial SOX18-mevalonate pathway axis enables ... - bioRxiv

SOX18 is a firmly established transcriptional regulator of vascular and lymphatic development, and tumor angiogenesis (11–14, 25, 34). The small ...

Infantile hemangioma: the common and enigmatic vascular tumor - JCI

Propranolol targets the endothelial transcription factor SOX18 to inhibit vasculogenesis in IH. ... R (+) propranolol inhibits SOX18 by ...

R-propranolol is a small molecule inhibitor of the SOX18 ...

R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma. Overman J 1 ,.

Homodimerization regulates an endothelial specific signature of the ...

Overall, we show that dimerization is a specific feature of SOX18 that enables the recruitment of key endothelial transcription factors, and ...

Small-Molecule Inhibitors of the SOX18 Transcription Factor - OUCI

Small-Molecule Inhibitors of the SOX18 Transcription Factor ... Authors: Frank Fontaine; Jeroen Overman; Mehdi Moustaqil; Sreeman Mamidyala; Angela Salim; Kamesh ...

NF-κB-dependent repression of Sox18 transcription factor requires ...

Using selective inhibitors and specific siRNA-driven depletion of HDACs 1-3 in human lung microvascular endothelial cells (HLMVEC) we were able to demonstrate a ...