Small Interfering RNA
Small interfering RNA - Wikipedia
Small interfering RNA ... Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded non-coding RNA ...
Molecular Mechanisms and Biological Functions of siRNA - PMC
One of the most important advances in biology has been the discovery that siRNA (small interfering RNA) is able to regulate the expression of genes, by a ...
Therapeutic siRNA: state of the art - Nature
It theoretically can silence any disease-related genes in a sequence-specific manner, making small interfering RNA (siRNA) a promising ...
Small Interfering RNA - an overview | ScienceDirect Topics
Small interfering RNAs (siRNAs) are doublestranded RNAs of 20–25 nucleotide length, which silence translation of a particular mRNA through binding to the mRNA ...
Small Interfering RNA (siRNA) Therapy - StatPearls - NCBI Bookshelf
This activity focuses on small interfering RNA (siRNA) therapy, exemplified by FDA-approved agents such as patisiran, givosiran, lumasiran, inclisiran, ...
Small Interfering RNA - an overview | ScienceDirect Topics
Small interfering RNAs (siRNAs) are artificially synthesized 19–23 nucleotide long double-stranded RNA molecules. They are routinely used in molecular biology ...
siRNA is a double-stranded RNA molecule that is non-coding. It is also known as silencing RNA and short interfering RNA.
What is RNA Interference? | Ask a Scientist - Thermo Fisher Scientific
What is RNAi? ... What is RNAi? RNA stands for ribonucleic acid, a nucleic acid present in all living cells. RNAi is short for “RNA interference” ...
Small interfering RNA (siRNA)-based therapeutic applications ...
This review provides an encompassing summary of the siRNA-based therapeutic approaches against viruses while also addressing the obstacles that need to be ...
Gene silencing in mammals by small interfering RNAs - Nature
Key Points · A new method for elucidating gene function in mammals was discovered in 2000; it uses small double-stranded RNAs to interfere with gene expression.
Comprehensive Review of Small Interfering RNAs (siRNAs) | IJN
Small interfering RNA (siRNA) delivery by nanocarriers has been identified as a promising strategy in the study and treatment of cancer.
siRNA Versus miRNA as Therapeutics for Gene Silencing - Cell Press
Discovered a little over two decades ago, small interfering RNAs (siRNAs) and microRNAs (miRNAs) are noncoding RNAs with important roles in gene regulation.
Specificity of short interfering RNA determined through gene ... - PNAS
These results indicate that siRNA is a highly specific tool for targeted gene knockdown, establishing siRNA-mediated gene silencing as a reliable approach.
RNA interference (RNAi): by Nature Video - YouTube
explains how RNAi works and introduces the two main players: small interfering RNAs (siRNAs) and microRNAs (miRNAs). We take you on an audio ...
Small interfering RNA: Discovery, pharmacology and clinical ...
This introductory review describes the utility of siRNA, by exploring the underpinning biology, pharmacology, recent advances and clinical developments
MicroRNAs and small interfering RNAs can inhibit mRNA ... - PNAS
Here, we demonstrate that an endogenously encoded human miRNA is able to cleave an mRNA bearing fully complementary target sites, whereas an exogenously ...
Small Interfering RNA-Induced Transcriptional Gene Silencing in ...
These results demonstrate that siRNA-directed transcriptional silencing is conserved in mammals, providing a means to inhibit mammalian gene function.
siRNA - Small Interfering RNAs: Post-transcription Gene Silencing
As siRNA silences specific genes, it has important applications in both molecular biology research and therapeutic applications. In research, ...
Small (Short) Interfering RNA (siRNA) - Danaher Life Sciences
siRNA plays a major role in post-transcriptional gene silencing (PTGS) by binding to a homologous messenger RNA (mRNA) and triggering its destruction, thereby ...
Small circular interfering RNAs (sciRNAs) as a potent therapeutic ...
Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing. Hartmut Jahns, Hartmut Jahns Alnylam Pharmaceuticals, Inc.