Small Interfering RNAs Mediate Sequence|Independent Gene ...

Small interfering RNAs mediate sequence-independent gene ...

Small interfering (si) and short hairpin (sh) RNAs induce robust degradation of homologous mRNAs, making them a potent tool to achieve gene silencing in ...

Small Interfering RNAs Mediate Sequence-Independent Gene ...

The use of siRNA, delivered by expression constructs or directly as a treatment for numerous diseases, has been proposed. The observation that these ...

Small Interfering RNAs Mediate Sequence-Independent Gene ...

Small Interfering RNAs Mediate Sequence-Independent Gene. Suppression and Induce Immune Activation by Signaling through Toll-Like Receptor 3. 1. Katalin Karikó ...

Sequence-dependent stimulation of the mammalian innate immune ...

Short interfering RNAs (siRNAs) that mediate specific gene silencing through RNA interference (RNAi) are widely used to study gene function and are also ...

Therapeutic siRNA: state of the art - Nature

... genes in a sequence-specific manner, making small ... gene silencing mediated by miRNA-like recognition between siRNA and a mistargeted RNA.

(PDF) Small Interfering RNAs Mediate Sequence-Independent Gene ...

Small interfering (si) and short hairpin (sh) RNAs induce robust degradation of homologous mRNAs, making them a potent tool to achieve gene ...

Genomewide view of gene silencing by small interfering RNAs - PNAS

By using DNA microarrays to profile global gene expression, we have demonstrated that siRNA-mediated gene silencing has exquisite sequence specificity for the ...

Small Interfering RNA - an overview | ScienceDirect Topics

Small interfering RNAs (siRNAs) are usually small anti-sense RNAs, approximately 20–25 nucleotides in length. They are generated from double-stranded RNAs.

Small interfering RNA - Wikipedia

It interferes with the expression of specific genes with complementary nucleotide sequences by degrading messenger RNA (mRNA) after transcription, preventing ...

siRNA Versus miRNA as Therapeutics for Gene Silencing - Cell Press

Discovered a little over two decades ago, small interfering RNAs (siRNAs) and microRNAs (miRNAs) are noncoding RNAs with important roles in gene regulation.

Small Interfering RNA - an overview | ScienceDirect Topics

Double-stranded RNA-mediated interference (RNAi) is a simple and rapid method of silencing gene expression. The principle behind gene silencing is to degrade ...

Short interfering RNA-mediated interference of gene expression and ...

Gene silencing mediated by double-stranded RNA is a sequence-specific RNA degradation mechanism highly conserved in eukaryotes that serves as an antiviral ...

Inhibition of genes expression of SARS coronavirus by synthetic ...

RNA interference (RNAi) is triggered by the presence of a double-stranded RNA (dsRNA), and results in the silencing of homologous gene ...

siRNA - Applications - Horizon Discovery

This activated protein and nucleic acid complex can then elicit gene silencing by binding, through perfect complementarity, to a single target mRNA sequence, ...

Identification of essential genes in cultured mammalian cells using ...

We report the first RNAi-induced phenotypes in mammalian cultured cells using RNA interference mediated by duplexes of 21-nt RNAs. The 21 gene products ...

siRNA-mediated off-target gene silencing triggered by a 7 nt ...

One of the perceived advantages of using siRNA as a functional genomics tool is its ability to silence genes in an sequence-specific manner. ... Some of the off- ...

Gene Silencing Mediated by Small Interfering RNAs in Mammalian ...

In mammalian cells siRNA molecules are capable of specifically silencing gene expression without induction of the unspecific interferon response pathway. Thus, ...

What is SiRNA? - News-Medical

siRNA is a double-stranded RNA molecule that is non-coding. It is also known as silencing RNA and short interfering RNA. It is similar to microRNA (miRNA) and ...

Small interfering RNAs mediate seq - H1 Connect

Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3. Karikó K et al.

Small interfering RNA (siRNA)-based therapeutic applications ...

RNAi is a robust technique frequently employed to selectively suppress gene expression in a sequence-specific manner. The swift adaptability of ...