Small interfering RNA
Small interfering RNA - Wikipedia
Small interfering RNA ... Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded non-coding RNA ...
Molecular Mechanisms and Biological Functions of siRNA - PMC
One of the most important advances in biology has been the discovery that siRNA (small interfering RNA) is able to regulate the expression of genes, by a ...
Therapeutic siRNA: state of the art - Nature
It theoretically can silence any disease-related genes in a sequence-specific manner, making small interfering RNA (siRNA) a promising ...
Small Interfering RNA - an overview | ScienceDirect Topics
Small interfering RNAs (siRNAs) are artificially synthesized 19–23 nucleotide long double-stranded RNA molecules. They are routinely used in molecular biology ...
Small Interfering RNA - an overview | ScienceDirect Topics
Small Interfering RNA ... Small interfering RNA (siRNA), also known as short interfering RNA or silencing RNA, is a kind of non-coding double-stranded RNA ...
siRNA is a double-stranded RNA molecule that is non-coding. It is also known as silencing RNA and short interfering RNA. It is similar to microRNA (miRNA) and ...
Small interfering RNA (siRNA)-based therapeutic applications ...
For example, small interfering RNAs (siRNAs) are produced on the basis of sequence complementarity to target and degrade viral RNA, a novel ...
What is RNA Interference? | Ask a Scientist - Thermo Fisher Scientific
What is RNAi? ... What is RNAi? RNA stands for ribonucleic acid, a nucleic acid present in all living cells. RNAi is short for “RNA interference” ...
Small Interfering RNA (siRNA) Therapy - StatPearls - NCBI Bookshelf
This activity focuses on small interfering RNA (siRNA) therapy, exemplified by FDA-approved agents such as patisiran, givosiran, lumasiran, inclisiran, ...
Gene silencing in mammals by small interfering RNAs - Nature
Key Points · A new method for elucidating gene function in mammals was discovered in 2000; it uses small double-stranded RNAs to interfere with gene expression.
Comprehensive Review of Small Interfering RNAs (siRNAs) | IJN
Short nucleotide sequences are synthesized exogenously to create siRNA, which triggers RNA interference (RNAi) in cells and silences target gene ...
siRNA Versus miRNA as Therapeutics for Gene Silencing - Cell Press
Discovered a little over two decades ago, small interfering RNAs (siRNAs) and microRNAs (miRNAs) are noncoding RNAs with important roles in gene regulation.
Specificity of short interfering RNA determined through gene ... - PNAS
For siRNAs to be a useful tool in gene knockdown experiments, it is critical that siRNA-mediated transcriptional silencing be specific. It is not enough to ...
RNA interference (RNAi): by Nature Video - YouTube
explains how RNAi works and introduces the two main players: small interfering RNAs (siRNAs) and microRNAs (miRNAs). We take you on an audio ...
Small interfering RNA: Discovery, pharmacology and clinical ...
To provide a suitable pharmacological profile for systemic therapy, and maximise efficacy, it is necessary to modify naked siRNAs. This has been ...
MicroRNAs and small interfering RNAs can inhibit mRNA ... - PNAS
Here, we demonstrate that an endogenously encoded human miRNA is able to cleave an mRNA bearing fully complementary target sites, whereas an exogenously ...
Small Interfering RNA-Induced Transcriptional Gene Silencing in ...
Transcriptional gene silencing in mammalian cells is often accompanied by cytosine DNA methylation, and de novo DNA methylation in plants is guided by small ...
siRNA - Small Interfering RNAs: Post-transcription Gene Silencing
As siRNA silences specific genes, it has important applications in both molecular biology research and therapeutic applications. In research, ...
Small (Short) Interfering RNA (siRNA) - Danaher Life Sciences
siRNA plays a major role in post-transcriptional gene silencing (PTGS) by binding to a homologous messenger RNA (mRNA) and triggering its destruction, thereby ...
Small circular interfering RNAs (sciRNAs) as a potent therapeutic ...
Covalently closed circular RNA transcripts are prevalent in eukaryotes and have potential as biomarkers and disease targets, and circular RNA ...