Small molecule|driven NLRP3 inflammation inhibition via interplay ...

Small molecule-driven NLRP3 inflammation inhibition via interplay ...

Our study indicated that NLRP3 (NLR family, pyrin domain containing 3) inflammasome is involved in Parkinson disease (PD) progression in patients and various ...

Small molecule-driven NLRP3 inflammation inhibition via interplay ...

In addition, the small molecule kaempferol (Ka) protected mice against LPS- and SNCA-induced neurodegeneration by inhibiting NLRP3 inflammasome activation as ...

Small molecule-driven NLRP3 inflammation inhibition via interplay ...

Request PDF | Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease ...

Interplay Between NLRP3 Inflammasome and Autophagy - Frontiers

Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease. Autophagy. (2019) ...

Small molecule inhibitor binds to NOD-like receptor family pyrin ...

Canonical NLRP3 inflammasome activation consists of a 2-step activation process. Transcriptional priming can occur through bacterial LPS binding ...

Novel Small-Molecule Inhibitor of NLRP3 Inflammasome Reverses ...

... via pattern recognition receptors and are responsible for the activation of inflammatory responses. (1) The core components of the inflammasome ...

Recent advances in the mechanisms of NLRP3 inflammasome ...

Using G5, a small-molecule inhibitor of deubiquitination, Py et al. ... Dopamine controls systemic inflammation through inhibition of NLRP3 ...

Discovery and characterization of small-molecule inhibitors of ...

MCC950, a specific small molecule inhibitor of NLRP3 inflammasome ... Systemic inflammation impairs microglial Aβ clearance through NLRP 3 ...

The NLRP3 Inflammasome Pathway: A Review of Mechanisms and ...

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. ... inflammation through inhibition of NLRP3 inflammasome ...

The interplay between α-Synuclein and NLRP3 inflammasome in ...

Sun, et al. Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease. J ...

MCC950, a specific small molecule inhibitor of NLRP3 ... - Nature

Complete inhibition with MCC950 in Winnie colonic explants shows, for the first time, the contribution of inflammatory effects resulting ...

Small molecule‐driven SIRT3‐autophagy‐mediated NLRP3 ...

AEDC attenuated the inflammatory crosstalk between macrophages and adipocytes through SIRT3-autophagy-mediated NLRP3 inflammasome inhibition.

Identification of a selective and direct NLRP3 inhibitor to treat ...

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases . ... inflammation through inhibition of NLRP3 ...

Mefloquine targets NLRP3 to reduce lipopolysaccharide‐induced ...

... Small molecule‐driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease.

Interrogating direct NLRP3 engagement and functional ... - Cell Press

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases ... via inhibiting NLRP3 inflammasome ...

NLRP3 Inflammasome Inhibitors for Antiepileptogenic Drug ... - MDPI

Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: Implications for Parkinson disease. Autophagy 2019 ...

Inhibitors of the NLRP3 inflammasome pathway as promising ...

... via a direct interaction ... small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice.

Small molecule inhibitor of the NLRP3 inflammasome for treating ...

The effects of JT002 treatment on hepatic and systemic inflammation and liver fibrosis were evaluated in vivo using a murine Nlrp3 knock-in (KI) ...

Small-molecule inhibitors of the NLRP3 inflammasome.

... NLRP3 inflammasome-mediated neuroinflammation in PD, future studies using these methods ... View in full-text. Context 2 ... NLRP3 inflammasome activation in ...

Role of NLRP3 Inflammasome and Its Inhibitors as Emerging ...

... inflammation through inhibition of NLRP3 ... A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.