Small molecules induce trained immunity

Small molecules induce trained immunity, opening a new approach ...

In the Esser-Kahn lab, Knight set out to find out whether any small molecules — drugs that can easily enter cells — could also induce trained ...

High-throughput screen identifies non inflammatory small molecule ...

Few molecules induce trained immunity; we report the identification of dozens of small molecule inducers of trained immunity identified through high-throughput ...

High-throughput screen identifies non inflammatory small molecule ...

We identified over two dozen small molecules in several chemical classes that induce a training phenotype in the absence of initial immune activation.

Small molecule inducers of trained immunity found

Researchers screened over 2000 small molecules and have now more than doubled the known compounds reported to induce trained immunity.

Novel non-immunogenic trained immunity inducing small molecule ...

We report a novel non-immunogenic trained immunity inducing molecule-A1155463-an inhibitor of the anti-apoptotic Bcl-xL protein.

Regulating trained immunity with nanomedicine - Nature

A range of metabolic and epigenetic pathways have been identified to regulate trained immunity (Fig. 1), and a wealth of small-molecule ...

High-throughput screen identifies non inflammatory small ... - PNAS

Few molecules induce trained immunity; we report the identification of dozens of small molecule inducers of trained immunity identified through ...

High-throughput screen identifies non-inflammatory small molecule ...

Small molecules with tunable pharmacokinetics and delivery modalities may be better suited for inducing trained immunity in therapeutic settings ...

Trained immunity — basic concepts and contributions to ... - Nature

Innate immune cells recognize pathogen-associated molecular patterns (PAMPs) via pattern recognition receptors (PRRs) expressed on their surface ...

Retraining Immunity: Small Molecules Offer New Disease Defense

Researchers discover steroid candidates for inducing trained immunity, opening a new approach to fighting disease.

Small-molecule screening identifies Syk kinase inhibition and ...

(A) Assay design to test modulation of b-glucan-induced innate immune training. TNF reporter THP1 cells were treated with 5 ng/mL b-glucan ...

GSE270608 - GEO Accession viewer

Small molecules with tunable pharmacokinetics and delivery modalities would both assist in the study of trained immunity and its future ...

Trained innate immunity: Concept, nomenclature, and future ...

Furthermore, novel trained immunity–inducing drugs, spanning from the discovery and development of small molecules with modulatory effects on epigenetic and ...

Trained immunity: Target for prophylaxis and therapy - ScienceDirect

On the one hand, we argue that novel approaches that induce trained immunity may enhance vaccine efficacy. On the other hand, induction of trained immunity in ...

Trained Immunity Carried by Non-immune Cells - Frontiers

Metabolic induction is additional mechanisms underlying trained immunity (Bekkering et al., 2018). Following pioneering work by Netea, the ...

Trained immunity: General and emerging concepts - Vuscan - 2024

Interestingly, fumarate by itself can induce innate immune training by inhibiting the lysine demethylase enzyme KDM5, thus increasing the ...

Trained immunity is regulated by T cell-induced CD40-TRAF6 ...

Combined, our results reveal that trained immunity is modulated by CD40-TRAF6 signaling between myeloid and adaptive immune cells and that this can be leveraged ...

High-throughput screen identifies non inflammatory ... - NASA ADS

Few molecules induce trained immunity; we report the identification of dozens of small molecule inducers of trained immunity identified through high ...

The causes and consequences of trained immunity in myeloid cells

Trained immunity is induced by innate immune cells, such as macrophages, monocytes, and NK cells, or in case of reentry of pathogen or vaccination. The ...

Novel non-immunogenic trained immunity inducing small molecule ...

A1155463 training improved anti-tumor resistance to B16.F10 melanoma cells. The effect was enhanced upon combination with checkpoint therapy. In ...