Solving Low Solubility Challenges to Optimize Drug Delivery Platforms

A number of enabling technologies have been developed to improve oral drug absorption and bioavailability (BA).

Insoluble drug delivery strategies: review of recent advances and ...

Issues associated with poor solubility can lead to low bioavailability resulting in suboptimal drug delivery. About 40% of drugs with market approval and nearly ...

REVIEW Solubilization techniques used for poorly water-soluble drugs

Low solubility reduces the drugability. Effectively improving the solubility and bioavailability of poorly water-soluble drugs is a critical ...

Improvement in solubility of poor water-soluble drugs by solid ...

Solid dispersion (SD) has been widely used to improve the dissolution rate, solubility, and oral absorption of poor water-soluble drugs.

Solving Tough Solubility Issues With Fewer Compromises & Better ...

To prevent API precipitation and improve bioavailability, it is crucial to add polymers that act as a “parachute” effect, keeping the drug in solution after ...

Solving Poor Solubility to Unlock a Drug's Potential - PharmTech

Poor solubility is an ongoing challenge in pharmaceutical development. A drug must be in solution form for it to be absorbed regardless of the ...

A Step towards Bioavailability Enhancement of Poorly Soluble Drugs

The most commonly utilized nanotechnology-based approaches for developing drug delivery systems include nanoemulsions, dendrimers, micelles, liposomes, solid ...

A solution for poor drug solubility | EUDRAGIT® polymers

About 90 % of drugs in clinical development are associated with poor drug solubility. Our EUDRAGIT® functional polymers can help you improve drug solubility ...

4 Factors Affecting Solubility of Drugs | Ascendia Pharmaceuticals

You may be able to improve dissolution rates of poorly soluble drugs by producing drug nanoparticles with a mean particle size below 1 μm.

Prodrug strategies to overcome poor water solubility - ScienceDirect

The use of a prodrug strategy as a chemical/biochemical approach to overcome various barriers which can hinder drug delivery, including solubility, is the ...

Technologies to Improve the Solubility, Dissolution and ... - MedCrave

Self-emulsifying drug delivery systems (SEDDS), SMEDDS and SNEDDS were explored in many studies as an efficient approach for improving the ...

Bioavailability Enhancement Techniques for Poorly Aqueous ... - MDPI

pH, additives, time, temperature, cosolvents, and ionic strength will affect the solution conditions. Pharmaceutical compounds with poor water solubility can ...

Breaking Barriers: New Developments in Oral Drug Delivery Systems

Nanoparticles like liposomes and polymeric nanoparticles can encapsulate these drugs, enhancing their aqueous solubility and bioavailability.

Supersaturating Drug Delivery Systems: The Answer to Solubility ...

The stabilization of a supersaturated solution can be accomplished by adding precipitation inhibitors which may act through a variety of mechanisms. The goal of ...

Advances in drug delivery systems, challenges and future directions

The physiochemical challenges are caused by poor water solubility, the high molecular weight of therapeutic proteins and peptides, and the ...

Engineering precision nanoparticles for drug delivery - Nature

NPs have the potential to improve the stability and solubility of encapsulated cargos, promote transport across membranes and prolong ...

Cosolvents in Self-Emulsifying Drug Delivery Systems (SEDDS)

Cosolvents in Self-Emulsifying Drug Delivery Systems (SEDDS): Do They Really Solve Our Solubility Problems? Click to copy article link ...

Nanotechnology Based Approaches for Enhancing Oral ...

There are several approaches to improve problems related to hydrophobic drugs. Among various approaches, nanotechnology based drug delivery ...

Lipid-based oral formulation in capsules to improve the delivery of ...

Poorly water-soluble drugs demonstrate significant challenge in pharmaceutical development, which is linked to their limited oral bioavailability and ...

Nano based drug delivery systems: recent developments and future ...

In particular, those drugs having poor solubility with less absorption ability are tagged with these nanoparticles [17, 29]. However, the ...