Spatial Organization of Signal Transduction Molecules in the NK ...

Spatial organization of signal transduction molecules in the NK cell ...

The cytolytic activity of NK cells is tightly regulated by inhibitory receptors specific for MHC class I Ags. We have investigated the ...

Translocation of signaling molecules from the cytosol to the NK cell plasma membrane occurs within a limited region of contact with the target cell. The complex ...

Spatial Organization of Signal Transduction Molecules in the NK ...

Spatial Organization of Signal Transduction Molecules in the. NK Cell Immune Synapses During MHC Class I-Regulated. Noncytolytic and Cytolytic Interactions.

Spatial organization of signal transduction molecules in the NK cell ...

Spatial organization of signal transduction molecules in the NK cell immune synapses during MHC class I-regulated noncytolytic and cytolytic interactions.

Spatial Organization of Signal Transduction Molecules in the NK ...

ArticlePDF Available. Spatial Organization of Signal Transduction Molecules in the NK Cell Immune Synapses During MHC Class I-Regulated Noncytolytic and ...

[PDF] Spatial Organization of Signal Transduction Molecules in the ...

It is demonstrated, in three-cell conjugates, that a single NK cell forms a cytolytic synapse with a susceptible target cell in the presence of both ...

Spatial Organization of Signal Transduction Molecules in the NK ...

Spatial Organization of Signal Transduction Molecules in the NK Cell Immune Synapses During MHC Class I-Regulated Noncytolytic and Cytolytic Interactions.

Spatial organization of signal transduction molecules in the NK cell ...

Spatial organization of signal transduction molecules in the NK cell immune synapses during MHC class I-regulated noncytolytic and cytolytic interactions · Files ...

Spatial Clustering of Receptors and Signaling Molecules Regulates ...

Natural Killer (NK) cell activation requires integration of inhibitory and activating signaling. Inhibitory signals are determined by ...

Spatial Organization of Signal Transduction Molecules in the NK ...

Abstract The cytolytic activity of NK cells is tightly regulated by inhibitory receptors specific for MHC class I Ags. We have investigated the composition ...

Signaling at the inhibitory natural killer cell immune synapse ... - PNAS

Rafts are known to carry many activating signal transduction molecules in other immune cell systems (5, 8, 9); the spatial organization of these molecules ...

Natural killer cell receptor signaling - ScienceDirect.com

Spatial organization of NK receptors on the membrane · NK receptor signaling: development and effector function · Conclusions · References and recommended reading.

Illuminating the dynamics of signal integration in Natural Killer cells

Natural Killer (NK) cell responses are shaped by the integration of signals transduced from multiple activating and inhibitory receptors at ...

Spatial organization and signal transduction at intercellular junctions.

The coordinated organization of cell membrane receptors into diverse micrometre-scale spatial patterns is emerging as an important theme of intercellular ...

Molecular-scale spatio-chemical control of the activating-inhibitory ...

... spatial arrangement of activating and inhibitory receptors and their signaling integration in NK cells. ... signal transduction. Science ...

Natural Killer Cell Inhibitory Receptors Block Actin Cytoskeleton ...

Spatial organization of signal transduction molecules in the NK cell immune synapses during MHC class I-regulated noncytolytic and cytolytic interactions. J ...

Spatial organization of transmembrane receptor signalling

The spatial organization of transmembrane receptors is a critical step in signal transduction and receptor trafficking in cells.

Structure of Natural Killer Receptor 2B4 Bound to CD48 ... - Cell Press

Among the receptors regulating NK cell function is 2B4 (CD244), a member of the signaling lymphocyte-activation molecule (SLAM) family that binds CD48. 2B4 is ...

The integration of signaling and the spatial organization of the T cell ...

Activation of T cells is a key element in adaptive immunity and requires the coordination of highly complex signal transduction networks (Figure ...

Natural killer cell cytotoxicity and its regulation by inhibitory receptors

NK cells tend to express many members of a given family of signalling molecules. The presence of many activating receptors and many members of a ...