Spatial control of membrane receptor function using ligand ...

Spatial control of membrane receptor function using ligand ... - Nature

Ligand nanocalipers made using DNA nanotechnology are used to display ephrin-A5 at well-defined spatial intervals to study how nanoscale ...

The spatial organization of membrane-bound ligands is thought to regulate receptor-mediated signaling. However, direct regulation of receptor function by ...

(PDF) Spatial control of membrane receptor function using ligand ...

The spatial organization of membrane-bound ligands is thought to regulate receptor-mediated signaling. However, direct regulation of receptor function by ...

Spatial control of membrane receptor function using ligand ...

Using ligand nanocalipers, we showed that the nanoscale spatial distribution of ephrin-A5 ligands tunes EphA2 receptor activation levels and the ...

Spatial control of membrane receptor function using ligand ...

Ligand nanocalipers made using DNA nanotechnology are used to display ephrin-A5 at well-defined spatial intervals to study how nanoscale ligand spacing ...

(PDF) Spatial control of membrane receptor function using ligand ...

TL;DR: It is shown that the nanoscale spacing of ephrin-A5 directs the levels of EphA2 receptor activation in human breast cancer cells and the ligand ...

Spatial control of membrane receptor function using ligand ... - CYTOO

... Spatial+control+of+membrane+receptor+function+using+ligand+nanocalipers. Keywords: Signaling; receptor; ligand; nanocaliper; breast cancer; membrane; ephrin-A5 ...

Controlled spatial characteristics of ligands on nanoparticles

Interactions between ligands and receptors play essential roles in controlling various cellular functions. In general, ligand-receptor interactions induce ...

Spatial control of membrane receptor function using ligand ...

Spatial control of membrane receptor function using ligand nanocalipers. by Alan Shaw, Vanessa Lundin, Ekaterina Petrova, Ferenc Fördős, Erik Benson, ...

Full control of ligand positioning reveals spatial thresholds for T cell ...

Elucidating the rules for receptor triggering in cell-cell and cell-matrix contacts requires precise control of ligand positioning in three ...

Physical-Chemical Regulation of Membrane Receptors Dynamics in ...

However, at the molecular or atomic level, protein molecules on the cell membrane are very flexible and mechanical force can induce membrane receptor ligand- ...

Control of cell membrane receptor condensation by adhesion to ...

The membrane contains receptors that can bind to their ligands anchored in the SLB. The specific receptor-ligand binding mediates the adhesion ...

Spatial regulation of membrane receptor signaling using DNA origami

However, the lateral distribution of receptors/ligands on the membrane has been gaining increasing significance in modulating intercellular ...

Spatial organization-dependent EphA2 transcriptional responses ...

Abstract. Ligand binding induces extensive spatial reorganization and clustering of the EphA2 receptor at the cell membrane.

Effect of Spatial Inhomogeneities on the Membrane Surface on ...

The membrane provides a platform for the reversible binding of ligands to receptors, initiating critical processes such as dimerization, activation of catalytic ...

Ligand entry pathways control the chemical space recognized by ...

Our work reveals that the receptor possesses two ligand entry channels: one lateral between transmembrane helices 4 and 5 facing the membrane, and one facing ...

Membrane receptor activation mechanisms and transmembrane ...

We discuss three major mechanistic hypotheses for receptor activation: ligand-induced dimerization, ligand-induced rotation, and receptor clustering.

Spatial organization of transmembrane receptor signalling

Several aspects of ligand‐induced receptor clustering and association with signalling proteins are also influenced by the lipid composition of ...

Spatial control of membrane receptor function using ... - Altmetric

Spatial control of membrane receptor function using ligand nanocalipers. Overview of attention for article published in Nature Methods, July 2014. Altmetric ...

Spatial Regulation of T-Cell Signaling by Programmed Death ...

; Teixeira, A. I. Spatial Control of Membrane Receptor Function Using Ligand Nanocalipers. Nat. Methods 2014, 11, 841– 846, DOI: 10.1038 ...