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Sphingolipids and Atherosclerosis

Sphingolipids and Atherosclerosis

Sphingolipids and Atherosclerosis: The Dual Role of Ceramide and ...

Sphingolipids are bioactive molecules that play either pro- and anti-atherogenic roles in the formation and maturation of atherosclerotic plaques.

Sphingolipids and atherosclerosis - ScienceDirect.com

Abstract. The atherosclerotic lesion contains a high amount of sphingolipids, a large group of structurally diverse lipids that regulate distinct biological ...

Sphingolipids Contribute to Human Atherosclerotic Plaque ...

Highlights. •. Glucosylceramide, lactosylceramide, ceramide, dihydroceramide, sphingomyelin, and sphingosine-1-phosphate were increased in human ...

Sphingolipids in Atherosclerosis: Chimeras in Structure and Function

Sphingolipids—a lipid class named after the chimeric creature sphinx—are considered to play a critical and, metaphorically, equally chimeric regulatory role in ...

Bioactive Sphingolipids as Major Regulators of Coronary Artery ...

The major lipids found in human atherosclerotic lesions are cholesterol, glycerophospholipids, and sphingolipids.

Ceramides and other sphingolipids as drivers of cardiovascular ...

A compelling body of evidence suggests that sphingolipids, such as ceramides, account for much of the tissue damage in these cardiometabolic ...

Ambient Air Pollution and Atherosclerosis: A Potential Mediating ...

Hence, sphingolipids may serve as biological intermediates mediating the proatherogenic effects (ie, elevated apoB-containing lipoprotein levels) ...

The Complex Tail of Circulating Sphingolipids in Atherosclerosis ...

We briefly review the sources of plasma SLs in atherosclerosis, the roles of SLs in CVD, and the possible use of the “ceramide score” as a prognostic marker ...

The therapeutic potential of sphingolipids for cardiovascular diseases

This review discusses the current understanding of sphingolipids' involvement in inflammation and cardiovascular diseases, the existing therapeutic approaches ...

Potential therapeutic targets for atherosclerosis in sphingolipid ...

CDase as a potential therapeutic target for atherosclerosis. Since inhibitors targetting ceramide biosynthesis are potential means for the treatment of ...

Sphingolipids in atherosclerosis and vascular biology

Such findings may provide new avenues for therapy for patients with atherosclerosis. The findings described here indicate an important role for sphingolipids in ...

The effect of dietary sphingolipids on plasma sphingomyelin ...

LDL retained in atherosclerotic lesions is acted on by an arterial wall sphingomyelinase (SMase), which appears to promote aggregation by generating ceramide [4] ...

Sphingolipids in atherosclerosis: a metabolic underpinning of ...

Although atherosclerotic plaque formation is driven primarily by cholesterol, new data suggest a proatherogenic role for sphingolipids.

Sphingolipids in the Heart: From Cradle to Grave - Frontiers

Much experimental evidence suggests that targeting sphingolipid metabolism may be advantageous in the context of cardiometabolic disease. The heart, however, is ...

Sphingolipids and Cardiovascular Diseases - SpringerLink

Heart disease is widely believed to develop from two pathological processes. Circulating lipoproteins containing the nondegradable lipid, cholesterol, ...

The features of sphingolipids' profile in patients with the family ...

Conclusions: The atherogenic variations of serum profiles of lipidome were revealed in patients with the family history of atherosclerosis. We speculate that ...

Sphingolipid Mediators of Myocardial Pathology

Ceramide regulates the hERG current (IHERG), which in turn regulates contractions and electrical activity of the heart via K+ ion channels.122, ...

Sphingolipids in cardiovascular diseases and metabolic disorders

Many investigations suggest the pivotal role of sphingolipids in the pathogenesis of lifestyle diseases such as myocardial infarction, ...

Regulation of Sphingolipid Metabolism by MicroRNAs: A Potential ...

Sphingolipid biosynthetic pathways involve various enzymes that lead to the formation of several key molecules implicated in atherosclerosis.

Plasma lipidomic analysis of sphingolipids in patients with large ...

Background: Sphingolipids mainly consist of ceramides (Cer), sphingomyelins (SM) and glycosphingolipids. Sphingolipids are related with coronary heart ...