Stable isotope tracing to assess tumor metabolism in vivo

Stable isotope tracing to assess tumor metabolism in vivo - Nature

We have developed methods to use stable isotope-labeled nutrients (eg, [ 13 C]glucose) to probe metabolic activity within intact tumors in vivo, in mice and ...

Stable isotope tracing to assess tumor metabolism in vivo · 1 : Patient infusion workflow. · 2 : Mouse infusion workflow. · 3 : Mouse infusion apparatus. · 4 : ...

Physiological impact of in vivo stable isotope tracing on cancer ...

There is growing interest in the analysis of tumor metabolism to identify cancer-specific metabolic vulnerabilities and therapeutic targets.

Stable isotope tracing to assess tumor metabolism in vivo

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Isotope tracing reveals glycolysis and oxidative metabolism in ...

Several recent studies have used intra-operative infusions with stable isotope-labeled nutrients, particularly 13C-glucose, to assess tumor ...

Metabolic pathway analysis using stable isotopes in patients with ...

This Review focuses on stable-isotope tracing to analyse tumour metabolism in vivo (Fig. ... Lower left, future tracing studies should assess ...

In vivo isotope tracing reveals a requirement for the electron ...

To choose models to examine the impact of complex I on tumor metabolism in vivo, we assessed the effects of IACS-010759 in a panel of cell lines ...

Stable Isotopes for Tracing Mammalian-Cell Metabolism in vivo - Lirias

By replacing circulating albumin by this 15N-labeled analog in tumor-bearing mice and assessing 15N enrichment in tissue amino acids, the authors could ...

Tracing metabolic flux in vivo: basic model structures of tracer ...

We will then review the basic principles and models of stable isotope tracer methodology that can be used to assess in vivo kinetics at the whole-body and ...

Stable Isotope Tracing Analysis in Cancer Research - MDPI

Stable isotope tracing is a powerful technique used in metabolic research to investigate the pathways and dynamics of biochemical reactions within biological ...

13C tracer analysis suggests extensive recycling of endogenous ...

Stable isotope tracing has been used to probe specific metabolic ... Ex vivo and in vivo stable isotope labelling of central carbon ...

Optimized protocol for stable isotope tracing and steady-state ...

Analyzing the metabolic dependencies of tumor cells is vital for cancer diagnosis and treatment. ... For in vivo steady state metabolite analysis, ...

Stable Isotopes for Tracing Mammalian-Cell Metabolism In Vivo

Metabolic models integrating stable-isotope tracer measurements in tissues and plasma allow quantitative readouts of in vivo metabolism at the whole-organ/whole ...

Untargeted stable isotope-resolved metabolomics to assess the ...

Stable isotope tracing to assess tumor metabolism in vivo. Nat. Protoc. 16, 5123–5145. doi:10.1038/s41596-021-00605-2. PubMed Abstract ...

TMET-28. A METHOD FOR EX VIVO STABLE ISOTOPE TRACING ...

Abstract. Stable isotope tracing is a powerful method for elucidating tumor metabolism. While in vivo stable isotope tracing is one of the ...

Stable isotope tracing in vivo reveals a metabolic bridge ... - Cell Press

To assess the impact of the microbiota on histone modifications in the distal gut, we prepared histone extracts from cecal and colonic ...

Stable Isotope Tracing Metabolomics to Investigate the Metabolic ...

... isotope tracing metabolomics to examine the metabolic alterations mediated by bioactive compounds in cancer ... tumor growth in vitro and in vivo by ...

Stable Isotope Tracing Analysis in Cancer Research - OUCI

Faubert, Stable isotope tracing to assess tumor metabolism in vivo, Nat. Protoc., № 16, с. 5123 https://doi.org/10.1038/s41596-021-00605-2; Llufrio, Systems ...

1 Human plasma-like medium facilitates metabolic tracing and ...

... Stable isotope tracing to assess tumor metabolism in vivo. Nature Protocols 16: 5123-5145 doi:10.1038/s41596-021-00605-2. 8. Jacob F, Salinas ...

In Vitro Tracking of Intracellular Metabolism-Derived Cancer ...

We developed a metabolism tracking approach combining stable isotope labeling and flux analysis of volatiles to trace the intracellular metabolism-derived ...