State of Gene Therapy for Monogenic Cardiovascular Diseases

Over the past 2 decades, significant efforts have been made to advance gene therapy into clinical practice. Although successful examples exist in other ...

Although successful examples exist in other fields, gene therapy for the treatment of monogenic cardiovascular diseases lags behind. In this review, we (1) ...

Gene Therapy in Cardiovascular Disease: Recent Advances and ...

Innovative strategies have emerged to rectify pathogenic variants that cause monogenic disorders such as hypertrophic, dilated, and ...

Gene Therapy for Cardiovascular Disease: Basic Research and ...

Monogenic inherited cardiovascular diseases are cardiovascular diseases caused by single gene mutation and conformed to the Mendelian genetic ...

Gene therapy for cardiac diseases: methods, challenges, and future ...

Recently, the cardiac gene therapy pipeline, which had progressed more slowly than in other fields, has begun to advance, overcoming biological and technical ...

Gene Therapy in Cardiovascular Disease - Professional Heart Daily

Many cardiovascular diseases, the leading cause of morbidity and mortality worldwide, are caused by damaging DNA variants and require ...

State of Gene Therapy for Monogenic Cardiovascular Diseases.

Over the past 2 decades, significant efforts have been made to advance gene therapy into clinical practice. Although successful examples ...

Gene therapy for heart failure and cardiomyopathies

Gene therapy has already received approval for treating genetic disorders like Leber's congenital amaurosis and spinal muscular atrophy.

On the Pulse of Gene Therapy: Continuing Progress in ... - HCPLive

Heart disease remains the leading cause of death for men and women of most ethnicities and racial groups in the United States, with 1 person ...

AHA SCIENCE ADVISORY - Gene Therapy in Cardiovascular Disease

ment on the state of genetic testing for cardiac diseases. Heart Rhythm ... monogenic cardiovascular disorders. J Am Coll Cardiol. 2020;76:797–808. doi ...

Genetic therapies for cardiomyopathy: survey of attitudes of ... - Nature

Expressivity is variable and while sometimes mild, complications can result in sudden cardiac death (SCD) at any age, heart failure and stroke.

State of Gene Therapy for Monogenic Cardiovascular Diseases - OUCI

State of Gene Therapy for Monogenic Cardiovascular Diseases. https://doi.org/10.1016/j.mayocp.2023.11.003 ·. Journal: Mayo Clinic Proceedings, 2024, № 4, p ...

Genetics May be Key to Monogenic Cardiovascular Disease

... conditions improve treatment. ... Monogenic cardiovascular diseases (MCVDs), including high-risk genetic conditions ...

A systematic review and meta-analysis of gene therapy with ... - Nature

Ex-vivo gene therapy (GT) with hematopoietic stem and progenitor cells (HSPCs) engineered with integrating vectors is a promising treatment ...

“One-and-done” gene therapies - KPMG International

polygenic disease states, (4) strategies for commercial success in monogenic gene therapy, and (5) guidance on pursuing acquisitions vs. partnerships to gain ...

Gene Therapy for Genetic Syndromes: Understanding the Current ...

Gene therapy holds promise as a life-changing option for individuals with genetic variants that give rise to disease. FDA-approved gene therapies for Spinal ...

Gene therapy of monogenic and cardiovascular disorders

Request PDF | Gene therapy of monogenic and cardiovascular disorders | The concept of gene therapy involves the introduction of genetic material into ...

Why Gene Therapies are Useful for More Than Monogenic Diseases

Gene therapy is a natural fit for addressing monogenic diseases; however, its application is much broader and there are numerous programs ...

Gene Therapy for Cardiovascular Disease - San Diego Heart Failure

State of Gene Therapy for Monogenic Cardiovascular Diseases. Mayo Clin Proc. 2024 Apr;99(4):610-629. doi: 10.1016/j.mayocp.2023.11.003. PMID ...

Gene therapy for polygenic or complex diseases | Biomarker Research

The initial focus of gene therapy was primarily directed towards monogenic diseases and cancer. Significant breakthroughs have been ...