Statistical methods for SNP heritability estimation and partition

In GWAS studies, SNP heritability measures the proportion of phenotypic variance explained by all measured SNPs. Accurate estimation of SNP ...

We present a comprehensive review on a broad category of recently developed and commonly used SNP heritability estimation methods.

A review of SNP heritability estimation methods - PubMed

Over the past decade, statistical methods have been developed to estimate single nucleotide polymorphism (SNP) heritability, which measures ...

(PDF) Statistical methods for SNP heritability estimation and partition

In GWAS studies, SNP heritability measures the proportion of phenotypic variance explained by all measured SNPs. Accurate estimation of SNP ...

Statistical methods for SNP heritability estimation and partition

Statistical methods for SNP heritability estimation and partition: A review · Huanhuan Zhu, Xiaoping Zhou · Published in Computational and Structural… 18 June ...

How to estimate heritability: a guide for genetic epidemiologists

'GREML only captures direct, additive effects of common SNPs' and not rare genetic effects or non-additive genetic effects. SNP-based methods ...

Improved heritability partitioning and enrichment analyses using ...

Stratified LD score regression (S-LDSC) is a widely used method-of-moments estimator for heritability enrichment, but S-LDSC has low statistical ...

Heritability Estimation Approaches Utilizing Genome‐Wide Data

LD score regression has been frequently applied to summary statistics from GWAS—to estimate the SNP-heritability of a trait, average bias due to ...

Statistical methods for SNP heritability estimation and partition - OUCI

Statistical methods for SNP heritability estimation and partition: A review · List of references · Publications that cite this publication.

Accurate and efficient estimation of local heritability using summary ...

... method for local heritability estimation—Heritability Estimation ... Statistical methods for snp heritability estimation and partition: a review.

Evaluation of heritability partitioning approaches in livestock ...

Heritability partitioning approaches estimate the contribution of different functional classes, such as coding or regulatory variants, ...

Partitioning heritability by functional annotation using genome

method that also estimates partitioned heritability but requires genotype data, in scenarios ... summary statistics with sufficient sample size, SNP-heritability ...

Partitioning gene-level contributions to complex-trait heritability by ...

Here, we introduce methods to estimate the proportion of phenotypic variance explained by a given assignment of SNPs to a single gene (“gene- ...

SNP‐based heritability and selection analyses: Improved models ...

Estimating the fraction of that is contributed by a given genome region, defined for example by functional annotations, was called 'genome ...

SNP‐based heritability and selection analyses - Minerva Access

Abstract. Complex-trait genetics has advanced dramatically through methods to estimate the heritability tagged by SNPs, both genome-wide and ...

Scalable summary statistics-based heritability estimation method ...

Methods that aim to estimate SNP heritability from individual genotype and phenotype data are limited by their ability to scale to Biobank ...

Leveraging LD eigenvalue regression to improve the estimation of ...

In this article, we propose LDER, a summary-statistics-based method improving the accuracy and precision of estimation of SNP heritability and ...

A review of SNP heritability estimation methods - ResearchGate

Over the past decade, statistical methods have been developed to estimate single nucleotide polymorphism (SNP) heritability, which measures the proportion ...

Using partitioned heritability methods to explore genetic architecture

Second, computationally efficient, partitioned LD score regression (LDSC) relates the LD tagging of common SNPs to their GWAS summary statistics ...

Leveraging LD eigenvalue regression to improve the estimation of ...

Compared to state-of-the-art heritability estimating methods, LDER provides more accurate estimates of SNP heritability and better distinguishes ...