Strategies for drugging undruggable targets in oncology

Recent advances in targeting the “undruggable” proteins: from drug ...

To make this review well organized, we discuss the design strategies targeting the undruggable proteins, including covalent regulation, ...

Emerging Pharmacotherapeutic Strategies to Overcome ... - NCBI

Based on the function of the target proteins in cancer, these undruggable targets can be classified as follows: (1) RAS family proteins. RAS ...

Drugging the 'undruggable' cancer targets - PMC

The term 'undruggable' was coined to describe proteins that could not be targeted pharmacologically. However, progress is being made to 'drug' many of these ...

Taking Aim at the Undruggable | American Society of Clinical ...

In cancer, some of these disease-modifying targets seem difficult to address; they seem “undruggable” because they lack accessible deep ...

Five strategies for drugging the undruggable - STAT News

Thousands of molecules in the body are known to influence disease, but creating medicines that can interact effectively with most of them is ...

Undruggable: The Current State of Drugging Cancer Targets

One successful example of FBDD in targeting an 'undruggable' cancer target is Vemurafenib, a drug used to treat melanoma. Vemurafenib ...

Drugging the "Undruggable" genes - Enzo

Cancer is one of the leading causes of death worldwide4 and the development of effective therapeutics is, therefore, one of the main targets for drug ...

Drugging The Undruggable Strategies And Future Directions

This article explores the potential of novel small molecule approaches to address undruggable targets in oncology, including PROteolysis ...

The Challenge of Drugging Undruggable Targets in Cancer

With the increasing realization of the importance of disrupting oncogenic protein-protein interaction, new challenges have emerged for classical ...

Drugging the undruggable proteins in cancer: A systems biology ...

Despite their large disease burdens, there are currently no clinically available therapeutics to modulate the activity of these targets [4]. This is commonly ...

TPD: turning undruggable targets into druggable targets

TPD is expected to challenge undruggable proteins, which are highly difficult to target by conventional small molecules. Unlike traditional drug ...

Strategies for drugging undruggable targets in oncology: From K ...

Strategies for drugging undruggable targets in oncology: From K-Ras to drug resistance - Kevan Shokat. ... cancer, and are generally associated with poor ...

(PDF) Strategies for targeting undruggable targets - ResearchGate

Expert opinion Targeting the undruggable expands the scope of therapeutically reachable targets. Consequently, it represents the drug discovery ...

Partnering to Turn the 'Undruggable' into Promising Targets | Pfizer

In the world of drug discovery, “undruggable” targets are like the stubborn children of biology, proteins that are considered too challenging to bind with ...

Unlocking the Potential of Undruggable Targets in Drug Discovery

RAS Biology: Unraveling the complexities of one of the most notorious targets in cancer research. · Induced Proximity: Harnessing molecular machineries to ...

Drugging the 'undruggable'. Therapeutic targeting of protein–DNA ...

Protein–DNA interactions remain one of the least explored target types in cancer therapeutics. This is largely because the protein–DNA surfaces are deemed ...

KRAS mutation: from undruggable to druggable in cancer - Nature

Unfortunately, despite 40 years of proprietary drug efforts, there are still no effective strategies targeting KRAS mutations, except for ...

Understanding Undruggable Targets Challenges And Progress

Some of the most recognizable include RAS, p53, MYC, and β-catenin.2 We have an intimate understanding of their roles in cancer but have only ...

Drugging the Undruggable Cancer Targets - ChemPartner

As clinical trials are vigorously advanced, efficacy, safety, resistance, and combination strategies are being carefully evaluated for those drug candidates. In ...

From Impossible to Inevitable: Transforming Undruggable Targets

Techniques such as fragment-based screening, which can utilize NMR or X-ray methods, are crucial for identifying these allosteric binders. These ...