Strategies to Address Low Drug Solubility in Discovery and ...

Strategies to address low drug solubility in discovery and development

Drugs with low water solubility are predisposed to low and variable oral bioavailability and, therefore, to variability in clinical response.

Here we provide a detailed commentary on the major challenges to the progression of a poorly water-soluble lead or development candidate.

(PDF) Strategies to Address Low Drug Solubility in Discovery and ...

Here we provide a detailed commentary on the major challenges to the progression of a poorly water-soluble lead or development candidate.

[PDF] Strategies to Address Low Drug Solubility in Discovery and ...

The article provides an integrated and contemporary discussion of current approaches to solubility and dissolution enhancement but has been deliberately ...

Strategies to Address Low Drug Solubility in Discovery and ...

In particular, we address the fundamental ... strategies available to those working with poorly water-soluble drugs. A. What Is Low Drug Solubility?

Strategies to address low drug solubility in discovery and ...

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Issues associated with poor solubility can lead to low bioavailability resulting in suboptimal drug delivery. About 40% of drugs with market approval and nearly ...

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Ravi M. Shanker; William N. Charman; Colin W. Pouton; Christopher J. H. Porter. List of references. Aakeröy, ...

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Drugs that have poor aqueous solubility have a slower drug absorption rate, which can lead to inadequate and variable bioavailability, and render the drug ...

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It may also lead to reduced membrane permeability and thus bioavailability. Overall, the poorly soluble compounds become a failure at the end of the drug ...

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(PDF) Strategies to Address Low Drug Solubility in Discovery and ...

Strategies to Address Low Drug Solubility in Discovery and Development. ... 461 Strategies for Low Drug Solubility 319 Abstract——Drugs with low water solubility ...

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This article describes the solubility challenge presented by many small molecule APIs and strategies to overcome these issues during the formulation ...

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Pharmaceutical compounds with poor water solubility can intensely decrease output in drug discovery and development. A “good compound” must reach the target ...

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There are several methods for achieving solid dispersion which include fusion (hot-melt), solvent evaporation, and hot-melt extrusion. A ...

Strategies To Address Low Drug Solubility PDF - Scribd

that it has a significant impact on dissolution rate. ... solubility dictates that increases in solubility inher- secondary in vitro assays and in vivo assessment ...

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Poorly soluble compounds can dramatically reduce productivity in drug discovery and development. Potential complications arising from low aqueous solubility: - ...

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Strategies to address low drug solubility in discovery and development. Pharmacol Rev 2013;65:315-499. 8. Chen H, Khemtong C, Yang X, Chang ...