Structural and chemical trapping of flavin‐oxide intermediates ...

Structural and chemical trapping of flavin-oxide intermediates ...

Though reactive flavin-N5/C4α-oxide intermediates can be spectroscopically profiled for some flavin-assisted enzymatic reactions, their exact chemical ...

The multifaceted flavin-dependent reaction continuum is physically dissected at molecular level for the first time.

Structural and chemical trapping of flavin‐oxide intermediates ...

The p‐hydroxy‐mandelate oxidase (Hmo) is a flavin mononucleotide (FMN)‐dependent oxidase catalyzing 2‐electron oxidation of α‐hydroxyacid to α‐ ...

Structural and chemical trapping of flavin-oxide intermediates ...

Abstract. Though reactive flavin-N5/C4α-oxide intermediates can be spectroscopically profiled for some flavin-assisted enzymatic reactions, ...

Structural and chemical trapping of flavin‐oxide intermediates ...

Abstract. Though reactive flavin-N5/C4α-oxide intermediates can be spectroscopically profiled for some flavin-assisted enzymatic reactions, ...

Structural and chemical trapping of flavin‐oxide intermediates revea

Though reactive flavin‐N5/C4α‐oxide intermediates can be spectroscopically profiled for some flavin‐assisted enzymatic reactions, their exac.

Structural and chemical trapping of flavin-oxide intermediates ... - 首頁

標題: Structural and chemical trapping of flavin-oxide intermediates reveals substrate-directed reaction multiplicity. 作者: Lin, K. H.

Sweating the assets of flavin cofactors: new insight of chemical ...

Chemical trapping of intermediates reveals the flavin forms N5 ... flavin-N5-oxide as an intermediate. 20•. R. Teufel, F. Stull, M.J. ...

Trapping of an intermediate in the reaction catalyzed by flavin ...

Several human pathogens rely on an alternative flavin-dependent thymidylate synthase (FDTS), which differs from the human TSase both in structure and molecular ...

On the Structure of Flavin-Oxygen Intermediates Involved in ...

During the catalytic reactions of flavoprotein hydroxylases and bacterial luciferase, flavin per- oxides are formed as intermediates [see Massey, ...

Insight into the Chemistry of Flavin Reduction and Oxidation in ...

Structural and chemical trapping of flavin‐oxide intermediates reveals substrate‐directed reaction multiplicity. Protein Science 2020, 29 (7) ...

Trapping conformational states of a flavin-dependent N ...

The structures also reveal protein conformational changes associated with the binding of NADP(H) and l-ornithine. Some of these residues were probed using site- ...

Chemical quenching and identification of intermediates in ...

... supplementing the information learned from spectroscopic, structural, and computational methods. Generally, in a chemical quench experiment, ...

Electronic Structure Methods for Simulating Flavin's Spectroscopy ...

trapping using uric acid as an alternative probe. The authors ... Quantum chemical calculation of excited states of flavin-related molecules.

Flavin‐Based Catalysis - the University of Groningen research portal

The UV/VIS-spectrum of the N5-oxide intermediate is in fact very similar to that of oxidized flavin. EncM is structurally not related to the group C ...

Trapping conformational states of a flavin-dependent N ... - OSTI.GOV

The siderophore biosynthetic enzyme A (SidA) ornithine hydroxylase from Aspergillus fumigatus is a fungal disease drug target involved in the production of ...

Trapping conformational states of a flavin-dependent N ...

The chemical structures of the top 10 ranked compounds for each site ... Flavin oxidation in flavin-dependent N-monooxygenases. Protein ...

Sweating the assets of flavin cofactors: new insight of chemical ...

Chemical trapping of intermediates reveals the flavin forms N5 covalent ... The first indication that flavoenzymes can make use of the flavin-N5-oxide as an ...

Sweating the assets of flavin cofactors: New insight of chemical ...

intermediate. In. combination. with. new. structures. (so-called. 'tight'. and ... 351:507-510. Chemical. trapping. of. intermediates. reveals. the. ﬂavin. forms.

N5 Is the New C4a: Biochemical Functionalization of Reduced ...

... flavin N5-oxide oxygenating intermediate. This proposal is supported by data ... intermediates in the oxidation of nitroethane by D-amino acid oxidase.