Structural and thermodynamic insights into antibody light ...

Structural and thermodynamic insights into antibody light chain ...

Overexpression of antibody light chains in small plasma cell clones can lead to misfolding and aggregation. On the other hand, the formation ...

Structural and thermodynamic insights into antibody light chain ...

According to data from X-ray crystallography, thermodynamic and kinetic measurements, as well as theoretical studies, this antibody light chain engages in 3D ...

[PDF] Structural and thermodynamic insights into antibody light ...

Structural and thermodynamic insights into antibody light chain tetramer formation through 3D domain swapping · Takahiro Sakai, Tsuyoshi Mashima, +8 authors

Structural and Thermodynamic Insights into Antibody Light Chain ...

While antibodies easily form aggregates and may lose the ability to recognize antigens, atomic-level structural examinations of antibody light chain aggregates ...

Structural and thermodynamic insights into antibody light chain ...

Downloadable! Overexpression of antibody light chains in small plasma cell clones can lead to misfolding and aggregation. On the other hand, the formation ...

Structural and Thermodynamic Insights into Antibody Light Chain ...

[Show full abstract] antibody light chain that maintains an equilibrium between its monomeric and tetrameric states. According to data from X- ...

Structural and thermodynamic insights into antibody light chain ...

Structural and thermodynamic insights into antibody light chain tetramer formation through 3D domain swapping ... Authors: Takahiro Sakai; Tsuyoshi Mashima; Naoya ...

Structural and Thermodynamical Insights into the Recognition of ...

The mechanism by which antibodies elicited against protein-derived peptides achieve cross-reactivity with their cognate proteins remains unknown.

First observation of structures resulting from 3D domain swapping in ...

Hirota concludes: “These findings not only clarify the domain-swapped structure of the antibody light chain but also contribute to controlling ...

Structural and Thermodynamic Insights into Dimerization Interfaces ...

The X-ray structure of GSTE1 was determined, unveiling remarkable thermal stability and a distinctive dimerization interface. Utilizing circular dichroism, we ...

Structural and thermodynamic basis for the recognition of ... - Nature

Single-domain antibodies (VHHs or nanobodies), developed from heavy chain-only antibodies of camelids, are gaining attention as ...

First observation of structures resulting from 3D domain swapping in ...

In a groundbreaking study, researchers now provide novel insights into the structure formed due to 3D domain swapping of the antibody light ...

An insight into the thermodynamic characteristics of human ...

The results shed light on the structural biology associated with neutralizing antibody recognition. Abbreviations. CL; constant region of ...

Thermodynamic and structural characterization of an antibody gel

We show the assembly of a monoclonal antibody, using multivalent carboxylate ions, into highly-ordered structures. While the presence and function of similar ...

Insights into the Structural Basis of Antibody Affinity Maturation from ...

Crystal structures of antibodies from these lineages bound to their target antigens have revealed, at the atomic level, how antibodies evolve to ...

Antibody Aggregation: Insights from Sequence and Structure - MDPI

The studies of aggregation mechanisms and resistant strategies for antibody domains have inspired the related research of full-length antibodies, although the ...

Structural insights into humanization of anti-tissue factor antibody ...

As a potential therapeutic, the antibody was humanized in a two-step procedure. Antigen-binding loops were grafted onto selected human frameworks and the ...

A First Insight into the Developability of an Immunoglobulin G3

Immunoglobulin G 3 (IgG3) monoclonal antibodies (mAbs) are high-value scaffolds for developing novel therapies. Despite their wide-ranging ...

Kinetic and thermodynamic insights into sodium ion translocation ...

To shed light on the molecular determinants, thermodynamics ... Structural insights into mu-opioid receptor activation. Nature. 2015 ...

A new pattern in antibody light chain tetramer formation

Column chromatography and X-ray crystal structure analyses revealed that the state where four antibody light chains aggregate to form a tetramer ...