Structural and thermodynamic insights into antibody light chain ...

Overexpression of antibody light chains in small plasma cell clones can lead to misfolding and aggregation. On the other hand, the formation ...

According to data from X-ray crystallography, thermodynamic and kinetic measurements, as well as theoretical studies, this antibody light chain engages in 3D ...

[PDF] Structural and thermodynamic insights into antibody light ...

An antibody light chain that maintains an equilibrium between its monomeric and tetrameric states is presented, and a pair of domain-swapped dimers creates ...

Structural and Thermodynamic Insights into Antibody Light Chain ...

While antibodies easily form aggregates and may lose the ability to recognize antigens, atomic-level structural examinations of antibody light chain aggregates ...

Structural and thermodynamic insights into antibody light chain ...

Downloadable! Overexpression of antibody light chains in small plasma cell clones can lead to misfolding and aggregation. On the other hand, the formation ...

Structural and Thermodynamic Insights into Antibody Light Chain ...

[Show full abstract] antibody light chain that maintains an equilibrium between its monomeric and tetrameric states. According to data from X- ...

Structural and thermodynamic insights into antibody light chain ...

AbstractOverexpression of antibody light chains in small plasma cell clones can lead to misfolding and aggregation. On the other hand, the formation of ...

First observation of structures resulting from 3D domain swapping in ...

Hirota concludes: “These findings not only clarify the domain-swapped structure of the antibody light chain but also contribute to controlling ...

Structural and Thermodynamical Insights into the Recognition of ...

The mechanism by which antibodies elicited against protein-derived peptides achieve cross-reactivity with their cognate proteins remains unknown.

First observation of structures resulting from 3D domain swapping in ...

Structural and thermodynamic insights into antibody light chain tetramer formation through 3D domain swapping. Nature Communications, 2023 ...

Structural and thermodynamic basis for the recognition of ... - Nature

... chain-only antibodies of ... Structural and thermodynamic insights into antibody light chain tetramer formation through 3D domain swapping.

A new pattern in antibody light chain tetramer formation

Column chromatography and X-ray crystal structure analyses revealed that the state where four antibody light chains aggregate to form a tetramer ...

An insight into the thermodynamic characteristics of human ...

Previously, the crystal structure of hTPO in complex with an antigen-binding fragment (Fab) derived from the hTPO-neutralizing murine monoclonal ...

Antibody Aggregation: Insights from Sequence and Structure - MDPI

Although the aggregation propensities of antibodies and antibody-based proteins can be affected by the external experimental conditions, they are strongly ...

Thermodynamic and structural characterization of an antibody gel

We show the assembly of a monoclonal antibody, using multivalent carboxylate ions, into highly-ordered structures. While the presence and function of similar ...

Antibodies gone bad – the molecular mechanism of light chain ...

In the 1970s, it became evident that the antibody sequences found in amyloids from different patients are diverse [[7]]. The proteins deposited ...

Structural insights into humanization of anti-tissue factor antibody ...

A hexahistidine tag was attached to the C-terminus of the heavy chain. The Fabs were transiently expressed in HEK 293 cells and purified using affinity and size ...

A First Insight into the Developability of an Immunoglobulin G3

(18) Furthermore, charge asymmetry between heavy and light chains has been correlated to increased self-association propensity, with increased ...

Structural insight into M-band assembly and mechanics from the titin ...

The carboxylate group of E92 interacts with the guanidinium group of OL1 R97, whilst the hydroxyl group of Y94 is H-bonded to the main-chain carbonyl oxygen of ...

Structural studies of neuropilin/antibody complexes provide insights ...

The cytoplasmic tail includes about 42–44 amino acids and does not display catalytic activity of its own, but presents a binding site for the PDZ domain of Nrp1 ...