Structure|Based Prediction of Asparagine and Aspartate ...

Structure-Based Prediction of Asparagine and Aspartate ... - PLOS

We derive an accurate in silico prediction method for the degradation propensity of both Asn and Asp residues in the complementarity-determining regions (CDRs) ...

Structure-based prediction of asparagine and aspartate degradation ...

We derive an accurate in silico prediction method for the degradation propensity of both Asn and Asp residues in the complementarity-determining regions (CDRs) ...

Structure-Based Prediction of Asparagine and Aspartate ...

We derive an accurate in silico prediction method for the degradation propensity of both Asn and Asp residues in the complementarity-determining regions (CDRs) ...

Structure-Based Prediction of Asparagine and Aspartate ... - PLOS

Deamidation of asparagine or dehydration of aspartic acid occurs by nucleophilic attack of the α-amino group of the C-terminally flanking amino acid. This leads ...

(PDF) Structure-Based Prediction of Asparagine and Aspartate ...

Asparagine and Aspartate degradation pathways.

Structure Based Prediction of Asparagine Deamidation Propensity in ...

Deamidation of neutrally charged asparagine (Asn) residues to negatively charged aspartate (Asp) or isoaspartate (isoAsp) residues is a common degradation ...

Structure-based prediction of asparagine and aspartate degradation ...

Structure-based prediction of asparagine and aspartate degradation sites in antibody variable regions. ... Monoclonal antibodies (mAbs) and ...

Structure-Based Prediction of Asparagine and Aspartate ... - OUCI

Structure-Based Prediction of Asparagine and Aspartate Degradation Sites in Antibody Variable Regions ... Автори: Jasmin F. Sydow; Florian Lipsmeier; Vincent ...

Structure-based prediction of asparagine and aspartate degradation ...

Therapeutic proteins may degrade via asparagine (Asn) deamidation and aspartate (Asp) isomerization, but the factors responsible for such degradation remain ...

Asparagine and Aspartate degradation pathways.

Deamidation of asparagine or dehydration of aspartic acid occurs by nucleophilic attack of the α-amino group of the C-terminally flanking amino acid.

Predicting deamidation and isomerization sites in therapeutic ...

Asparagine (Asn) deamidation and aspartic acid (Asp) isomerization are common degradation pathways that affect the stability of therapeutic antibodies.

Machine Learning Enables Accurate Prediction of Asparagine ...

The spontaneous conversion of asparagine residues to aspartic acid or iso-aspartic acid, via deamidation, is a major pathway of protein ...

Protein asparagine deamidation prediction based on structures with ...

This work introduces structure-based prediction models for asparagine (Asn) deamidation by mining available experimental and structural data of deamidated ...

NGOME-Lite: Proteome-wide prediction of spontaneous protein ...

Current prediction algorithms for asparagine deamidation require a structure as an input or are too slow to be applied at a proteomic scale. We present NGOME- ...

Asparagine and Aspartate degradation pathways. Deamidation of...

... Asp) are outlined with black boxes. from publication: Structure-Based Prediction of Asparagine and Aspartate Degradation Sites in Antibody Variable Regions ...

Formulation considerations for proteins susceptible to asparagine ...

The review is intended to provide information to formulation scientists, based on protein sequence and structure, to predict potential degradative sites on a ...

In Silico Prediction Method for Protein Asparagine Deamidation

The method is based on understanding deamidation mechanism on structural level with machine learning. Our structure-based method is more accurate than the ...

Conformational Control of Fast Asparagine Deamidation in a ...

Structure-based prediction of asparagine and aspartate degradation sites in antibody variable regions. PloS one 2014, 9 (6), e100736, DOI ...

Protein asparagine deamidation prediction based on structures with ...

In this work, we focus on prediction models for asparagine (Asn) deamidation. Sequence-based prediction method simply identifies the NG motif ( ...

Divining Deamidation and Isomerization in Therapeutic Proteins

Deamidation of asparagine (ASN) and isomerization of aspartic acid (ASP) residues are among the most commonly observed spontaneous post- ...