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Structure|based prediction of asparagine and aspartate degradation ...


Structure-Based Prediction of Asparagine and Aspartate ... - PLOS

Therapeutic proteins may degrade via asparagine (Asn) deamidation and aspartate (Asp) isomerization, but the factors responsible for such degradation remain ...

Structure-based prediction of asparagine and aspartate degradation ...

We derive an accurate in silico prediction method for the degradation propensity of both Asn and Asp residues in the complementarity-determining regions (CDRs) ...

Structure-Based Prediction of Asparagine and Aspartate ...

We derive an accurate in silico prediction method for the degradation propensity of both Asn and Asp residues in the complementarity-determining regions (CDRs) ...

Structure-Based Prediction of Asparagine and Aspartate ... - PLOS

Figure 1. Asparagine and Aspartate degradation pathways. Deamidation of asparagine or dehydration of aspartic acid occurs by nucleophilic attack of the α-amino ...

(PDF) Structure-Based Prediction of Asparagine and Aspartate ...

Therapeutic proteins may degrade via asparagine (Asn) deamidation and aspartate (Asp) isomerization, but the factors responsible for such degradation remain ...

Structure-based prediction of asparagine and aspartate degradation ...

Structure-based prediction of asparagine and aspartate degradation sites in antibody variable regions. by Jasmin F Sydow, Florian Lipsmeier, ...

Structure Based Prediction of Asparagine Deamidation Propensity in ...

Deamidation of neutrally charged asparagine (Asn) residues to negatively charged aspartate (Asp) or isoaspartate (isoAsp) residues is a common degradation ...

Structure-Based Prediction of Asparagine and Aspartate ... - OUCI

Structure-Based Prediction of Asparagine and Aspartate Degradation Sites in Antibody Variable Regions ... Автори: Jasmin F. Sydow; Florian Lipsmeier; Vincent ...

Structure-based prediction of asparagine and aspartate degradation ...

Monoclonal antibodies (mAbs) and proteins containing antibody domains are the most prevalent class of biotherapeutics in diverse indication areas.

Asparagine and Aspartate degradation pathways.

Structure-Based Prediction of Asparagine and Aspartate Degradation Sites in Antibody Variable Regions · PLOS ONE. Categories.

Machine Learning Enables Accurate Prediction of Asparagine ...

36. Sydow, J.F. ∙ Lipsmeier, F. ∙ Larraillet, V. ... Structure-based prediction of asparagine and aspartate degradation sites in antibody ...

Asparagine and Aspartate degradation pathways. Deamidation of...

... Asp) are outlined with black boxes. from publication: Structure-Based Prediction of Asparagine and Aspartate Degradation Sites in Antibody Variable Regions ...

Protein asparagine deamidation prediction based on structures with ...

This work introduces structure-based prediction models for asparagine ... Structure-Based Prediction of Asparagine and Aspartate Degradation Sites in Antibody ...

Analytical tools for the characterization of deamidation in ...

Structure-Based Prediction of Asparagine and Aspartate Degradation Sites in Antibody Variable Regions. PLoS ONE, 9 (2014), Article 100736, 10.1371/journal ...

In Silico Prediction Method for Protein Asparagine Deamidation

... Structure-based prediction of asparagine and aspartate degradation sites in antibody variable regions. PLoS One 9:e100736.https://doi.org/10.1371/journal ...

NGOME-Lite: Proteome-wide prediction of spontaneous protein ...

Sydow et al. Structure-Based Prediction of Asparagine and Aspartate Degradation Sites in Antibody Variable Regions. PLoS ONE. (2014). L. Jia et al. Protein ...

Divining Deamidation and Isomerization in Therapeutic Proteins

Sydow, J.F., et al., Structure-based prediction of asparagine and aspartate degradation sites in antibody variable regions. PLoS One, 2014 ...

Mechanisms of Deamidation of Asparagine Residues and Effects of ...

Structure-based prediction of asparagine and aspartate degradation sites in antibody variable regions. PLoS ONE 2014, 9, e100736. [Google ...

Divining Deamidation and Isomerization in Therapeutic Proteins

Sydow, J.F., et al., Structure-based prediction of asparagine and aspartate degradation sites in antibody variable regions. PLoS One , 2014 ...

Conformational Control of Fast Asparagine Deamidation in a ...

Structure-based prediction of asparagine and aspartate degradation sites in antibody variable regions. PloS one 2014, 9 (6), e100736, DOI ...