Structure and Function of the calcium|selective TRP channel TRPV6

Structure and function of the calcium-selective TRP channel TRPV6

Epithelial calcium channel TRPV6 is a member of the vanilloid subfamily of TRP channels that is permeable to cations and highly selective to Ca 2+ ...

Structure and function of the calcium‐selective TRP channel TRPV6

1999; Peng et al. 1999). While TRPV5, which expression is mainly restricted to the kidney, is considered the major epithelial calcium channel ...

Calcium selective channel TRPV6: Structure, function, and ...

Calcium-selective channel TRPV6 (Transient Receptor Potential channel family, Vanilloid subfamily member 6) belongs to the TRP family of ...

Calcium selective channel TRPV6: Structure, function, and ...

The TRPV6 protein is expressed in a range of epithelial tissues such as the intestine, kidney, placenta, epididymis, and exocrine glands such as ...

Calcium selective channel TRPV6: Structure, function, and ...

... Calcium-selective channel TRPV6 (Transient Receptor Potential channel family, Vanilloid subfamily. 3 member 6) belongs to the TRP family of cation channels ...

Full article: Molecular pharmacology of the onco-TRP channel TRPV6

TRPV6 plays a crucial role as a regulator of calcium balance in mammals. When the normal TRPV6 function is disturbed, it causes changes in ...

Structure and Function of the Epithelial Calcium Channel TRPV6

functions. The Ca2+-selective TRP channels TRPV5 and TRPV6 play vital roles in calcium homeostasis as Ca2+ uptake channels in epithelial tissues. We solved ...

Structural bases of TRP channel TRPV6 allosteric modulation by 2 ...

Ca2+ is a critical regulator of cell proliferation, suggesting a role for TRPV6 in the potentiation of calcium-dependent cell proliferation ...

Structure and Function of the Epithelial Calcium Channel TRPV6

Precise regulation of calcium homeostasis is essential for many physiological functions. The Ca2+-selective TRP channels TRPV5 and TRPV6 play vital roles in ...

The TRPV6 Calcium Channel and Its Relationship with Cancer - MDPI

After S6, the amphipathic TRP helix is aligned in parallel with the membrane. It functions as a central node where interactions between the hydrophilic and ...

Structure and function of the calcium‐selective TRP channel TRPV6

TRPV6 is a calcium-selective ion channel implicated in epithelial Ca2+uptake. TRPV6 inhibitors are needed for the treatment of a broad range of ...

CDC stacks

LinkedIn. File Format: RIS. Structure and Function of the calcium-selective TRP channel TRPV6. Published Date: February 19 2020. Source: J Physiol.

Structural mechanism of human oncochannel TRPV6 inhibition by ...

Calcium-selective oncochannel TRPV6 is the major driver of cell proliferation in human cancers. While significant effort has been invested ...

Calcium selective channel TRPV6: Structure, function, and ...

The TRP helix is followed by a six-residue β-strand (β3) that forms a β-sheet with β1 and β2 in the linker domain. Two helices located in the C-terminus of ...

TRPV6 - Wikipedia

TRPV6 is a membrane calcium (Ca) channel protein which is particularly involved in the first step in Caabsorption in the intestine.

Crystal structure of the epithelial calcium channel TRPV6 - OSTI.GOV

Precise regulation of calcium homeostasis is essential for many physiological functions. The Ca2+-selective transient receptor potential (TRP) channels ...

TRPV6 | SpringerLink

The ion channel TRPV6 is likely to function as an epithelial calcium channel in organs with high calcium transport requirements such as the intestine, kidney, ...

Inactivation-mimicking block of the epithelial calcium channel TRPV6

TRP channels are associated with a variety of genetic and acquired diseases and investigated as important drug targets (2). TRPV6, a member of ...

TRPV6 as A Target for Cancer Therapy

One member of the vanilloid sub-family of channels is TRPV6. This channel is highly selective for divalent cations, particularly calcium, and plays a part in ...

Calcium Selective Channel TRPV6: Structure, Function, and ...

... TRPV6 is a representative of the vanilloid subfamily of transient receptor potential (TRP) channels that serves as an entry gate for capturing dietary ...