Structure and decoy|mediated inhibition of the SOX18 ...

Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA ...

Genetic disruption of Sox18 in a mouse model protects from tumour metastasis and established the SOX18 protein as a molecular target. Here, we ...

Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA ...

The transcription factor (TF) SOX18 drives lymphatic vessel development in both embryogenesis and tumour-induced neo-lymphangiogenesis.

Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA ...

The crystal structure of the SOX18 DNA binding high-mobility group (HMG) box bound to a DNA element regulating Prox1 transcription is reported, ...

Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA ...

Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA interaction. Klaus, Miriam, Prokoph, Nina, Girbig, Mathias, Wang, Xuecong, Huang, Yong-Heng ...

Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA ...

Four decoys potently inhibited DNA binding of SOX18 in vitro and did not interact with non-SOX TFs. Serum stability, nuclease resistance and thermal ...

Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA ...

Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA interaction.Nucleic Acids Research. First author. Miriam Klaus, Nina Prokoph ...

Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA ...

Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA interaction. Klaus M, Prokoph N, Girbig M, Wang X, Huang YH, Srivastava Y, Hou L, Narasimhan ...

Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA ...

Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA interaction ... Authors: Miriam Klaus; Nina Prokoph; Mathias Girbig; Xuecong Wang; Yong-Heng Huang ...

Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA ...

Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA interaction. Miriam Klaus, Nina Prokoph, Mathias Girbig, Xuecong Wang, Yong ...

Structure and decoy-mediated inhibition of the SOX18 ... - Altmetric

Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA interaction · Nucleic Acids Research, March 2016 · 10.1093/nar/gkw130 · 26939885 · Miriam Klaus, Nina ...

Article Small-Molecule Inhibitors of the SOX18 Transcription Factor

... SOX18 inhibitors with structural similarities to COX inhibitors ... Francois, et al. Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA interaction.

Small-Molecule Inhibitors of the SOX18 Transcription Factor

), and SOX18 (Klaus et al., 2016. 28. Klaus, M. ∙ Prokoph, N. ∙ Girbig, M. ... Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA interaction.

Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA ...

Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA interaction. Miriam Klaus, Nina Prokoph, Mathias Girbig, Xuecong Wang, Yong Heng Huang, Yogesh ...

Modified SOX decoys potently inhibit DNA binding of SOX18. The ...

The left panel shows a scheme of the decoys and a structural cartoon of the termini to illustrate the modifications. (A) Unmodified decoy 'NAT', (B) 'PS' decoy ...

4y60 - Structure of SOX18-HMG/PROX1-DNA - Summary

Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA interaction. Nucleic Acids Res., 44:3922-3935, 2016. Cited by 42. PubMed: 26939885 · DOI: 10.1093 ...

Small-Molecule Inhibitors of the SOX18 Transcription Factor

In this study, we identified SOX18 inhibitors with structural similarities ... Structure and · decoy-mediated inhibition of the SOX18/Prox1-DNA interaction.

Role of the SOX18 protein in neoplastic processes (Review)

As a consequence, it was claimed that SOX18 inhibition ... Image from the RCSB PDB of 4Y60: Structure and decoy-mediated inhibition of the SOX18/ ...

Functional domain analysis of SOX18 transcription factor using a ...

... inhibit SOX18-mediated transcriptional activation, in a cell-based assay. ... Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA interaction.

Targeting SOX18 Transcription Factor Activity by Small-Molecule ...

... structure is not fully resolved. Moreover, little is known about the ... This suggests that Sm4-mediated SOX18 inhibition can activate ...

Homodimerization regulates an endothelial specific signature of the ...

et al. Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA interaction . Nucleic Acids Res. 2016. ;. 44. : 3922. –. 3935 . Google ...