Structure and function of lipid rafts in human activated T cells

Lipid rafts, specialized membrane microdomains enriched in sphingolipids and cholesterol, have been shown to function as signaling platforms in T cells.

Abstract. Lipid rafts, specialized membrane microdomains enriched in sphingolipids and cholesterol, have been shown to function as signaling ...

Structure and function of lipid rafts in human activated T cells

In fact,. GM3 is the major ganglioside on the plasma membrane of human peripheral blood lymphocytes and appears to play a functional role in raft-mediated T ...

Lipid rafts and their roles in T-cell activation - ScienceDirect.com

Lipid rafts are defined as detergent-resistant membrane microdomains of specific lipid and protein composition. They are involved in many aspects of cell ...

[PDF] Structure and function of lipid rafts in human activated T cells ...

The structure and function of lipid rafts in humanactivated T cells seem to be quite distinct from those in naive T cells, and human activated T cells are ...

Lipid rafts and T-lymphocyte function: Implications for autoimmunity

A structural feature that supports membrane segmentation implicates assemblies of selected lipids broadly referred to as lipid rafts. In T-lymphocytes, lipid ...

(PDF) Structure and function of lipid rafts in human activated T cells

PDF | Lipid rafts, specialized membrane microdomains enriched in sphingolipids and cholesterol, have been shown to function as signaling platforms in T..

The role of lipid rafts in T cell antigen receptor (TCR) signalling

Together the data suggest that lipid rafts are important in controlling appropriate protein interactions in resting and activated T cells, and that aggregation ...

Transcriptional Regulation of T-Cell Lipid Metabolism - Frontiers

Signaling molecules accumulate at high density in lipid rafts and they are essential for immune cell activation and function (5, 6). Cholesterol helps to ...

Lipid rafts and neurodegeneration: structural and functional roles in ...

These lipid rafts seem to organize and determine the function of multiprotein complexes involved in several aspects of signal transduction, thus regulating the ...

The role of lipid rafts in signalling and membrane trafficking in T ...

As in epithelial cells, rafts are used also as vesicular carriers for membrane trafficking in T lymphocytes. Furthermore, there are potential ...

Structure and function of lipid rafts in human activated T cells - OUCI

Garofalo, T., Lenti, L., Longo, A. et al.2002. Association of GM3 with Zap-70 induced by T cell activation in plasma membrane microdomains: GM3 as a marker of ...

Synthetic lipid rafts formed by cholesterol nano-patch induce T cell ...

The coalescence of small lipid rafts into a large lipid raft forms a signaling platform at the immunological synapse that plays a crucial role ...

Lipid rafts in immune signalling: current progress and future ...

Lipid raft-associated adaptor proteins LAT and non-T cell activation linker (NTAL) act as the positive and negative regulators of FcεRI ...

Primary Human CD4 + T Cells Have Diverse Levels of Membrane ...

Membrane lipid microdomains (lipid rafts) play an important role in T cell function by forming areas of high lipid order that facilitate activation.

CD4 and CD8 T cells require different membrane gangliosides for ...

Molecules called gangliosides are known to be major components of lipid rafts, but their role in T-cell activation has not been established. Here, we show that ...

Lipid Rafts: Cell

It has been suggested that such rafts could play an important role in many cellular processes including signal transduction, membrane trafficking, cytoskeletal ...

Role of Lipid Rafts in Pathogen-Host Interaction - A Mini Review

Low doses of ROS under steady-state conditions contribute to cell survival, whereas high doses of ROS induced by infection help clear pathogens by activating ...

Free Cholesterol Alters Lipid Raft Structure and Function Regulating ...

Rafts are thought to concentrate membrane signaling molecules and thus regulate cell signaling through G protein-coupled pathways. We used methyl β-cyclodextrin ...

Lipid raft - Wikipedia

The plasma membranes of cells contain combinations of glycosphingolipids, cholesterol and protein receptors organised in glycolipoprotein lipid microdomains ...