Structure of the Rad50 DNA double‐strand break repair protein in ...

Structure of the Rad50 DNA double-strand break repair protein in ...

We determined the crystal structure of Thermotoga maritima Rad50 NBD (nucleotide-binding domain) in complex with Mre11 HLH (helix-loop-helix domain), AMPPNP, ...

Structure of the Rad50 DNA double-strand break repair protein in ...

The Mre11-Rad50 nuclease-ATPase is an evolutionarily conserved multifunctional DNA double-strand break (DSB) repair factor.

Structure of the Rad50 DNA double‐strand break repair protein in ...

Synopsis. image. The SMC protein Rad50 is a key subunit of the MRN complex, a repair factor involved in processing and tethering DNA double‐strand breaks. First ...

Rad50 - an overview | ScienceDirect Topics

DNA double strand break repair in mammalian cells ... Rad50 is an ATP-dependent DNA-binding protein. Mre11 has several activities, the most important of which may ...

MRE11-RAD50-NBS1 complex alterations and DNA damage ...

It functions in both DSB sensing and repair. In sensing stage, MRN complex is recruited to broken sites by γ-H2AX and RAD17 [31], both of which ...

DNA repair protein RAD50 - Homo sapiens (Human) | UniProtKB

RAD50 provides an ATP-dependent control of MRE11 by positioning DNA ends into the MRE11 active site: ATP-binding induces a large structural change from an open ...

Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the ...

The DNA double-strand break repair complex Mre11-Rad50-Nbs1 (MRN) detects and nucleolytically processes DNA ends, activates the ATM kinase, and tethers DNA at ...

Mre11-Rad50 oligomerization promotes DNA double-strand break ...

We demonstrate that Mre11-Rad50-Xrs2 oligomerization facilitates foci formation, DNA damage signaling, repair, and telomere maintenance in vivo.

The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular ...

The MR (Mre11 nuclease and Rad50 ABC ATPase) complex is an evolutionarily conserved sensor for DNA double-strand breaks, highly genotoxic lesions linked to ...

rad50 - DNA double-strand break repair Rad50 ATPase | UniProtKB

Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the ...

Structural Biochemistry and Interaction Architecture of the DNA ...

To clarify functions of the Mre11/Rad50 (MR) complex in DNA double-strand break repair, we report Pyrococcus furiosus Mre11 crystal structures, ...

Rad50 - Wikipedia

Rad50 ; RAD50, NBSLD, RAD502, hRad50, Rad50, RAD50 double strand break repair protein · OMIM: 604040, 613078; MGI: 109292; HomoloGene: 38092; GeneCards: RAD50; ...

Turning the Mre11/Rad50 DNA repair complex on its head

DNA double-strand breaks (DSBs), where both strands of the DNA duplex are concurrently broken, represent some of the most cytotoxic forms of ...

The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular ...

Semantic Scholar extracted view of "The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break Repair" by K. Lammens et al.

RAD50 Double Strand Break Repair Protein - GeneCards

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair.

The Mre11/Rad50 complex - an ATP dependent molecular clamp in ...

Structural biology · The Mre11/Rad50 complex - an ATP dependent molecular clamp in DNA double strand break repair.

DNA double-strand break repair Rad50 ATPase, archaeal type

DNA double-strand break repair Rad50 ATPase, archaeal type ; Overview ; Proteins 848 ; Taxonomy 1k ; Proteomes 187 ; AlphaFold 733 ...

Structure of the Rad50 DNA double-strand break repair protein in ...

; Rojowska, Anna ;, ISSN: 0261-4189 , 1460-2075 ;, The EMBO journal. , 2014, Vol.33(23), p.2847-2859 ...

Mre11–Rad50: the DNA end game | Biochemical Society Transactions

The Mre11–Rad50-(Nbs1/Xrs2) complex is an evolutionarily conserved factor for the repair of DNA double-strand breaks and other DNA termini in all kingdoms of ...

Structure of the Rad50 DNA double-strand break repair protein in ...

The Mre11–Rad50 nuclease–ATPase is an evolutionarily conserved multifunctional DNA double‐strand break (DSB) repair factor. Mre11–Rad50's mechanism in the ...