Structure of the human SAGA coactivator complex

Structure of the human SAGA coactivator complex - Nature

The SAGA complex is a regulatory hub involved in gene regulation, chromatin modification, DNA damage repair and signaling. While structures ...

Structure of the human SAGA coactivator complex - PubMed

The SAGA complex is a regulatory hub involved in gene regulation, chromatin modification, DNA damage repair and signaling. While structures ...

Cryo-EM structure of human SAGA transcriptional coactivator complex

Here we report the cryo-EM structure of endogenous hSAGA coactivator complex purified from HEK293 cells at an overall resolution of 3.7 Å.

Structure of the human SAGA coactivator complex - Library Search

The SAGA complex is a regulatory hub involved in gene regulation, chromatin modification, DNA damage repair and signaling. While structures of yeast SAGA ...

Structure of the human SAGA coactivator complex - bioRxiv

Our 2.9 Å structure of human SAGA reveals intertwined functional modules flexibly connected to a core that distinctively integrates mammalian ...

Cryo-EM structure of human SAGA transcriptional coactivator complex

In summary, our cryo-EM analysis reveals that human SAGA complex adopts an overall architecture distinct from yeast SAGA complex due to the ...

Conservation and diversity of the eukaryotic SAGA coactivator ...

The SAGA complex is an evolutionarily conserved transcriptional coactivator that regulates gene expression through its histone acetyltransferase and ...

7KTS: Negative stain EM structure of the human SAGA coactivator ...

Structure of the human SAGA coactivator complex. ; Reference Sequence. 7KTS_2. 0 50 100 150 200 250 300 350 400 450 500 550. 7KTS_2.

Structure of the human SAGA coactivator complex - OSTI.GOV

Abstract The SAGA complex is a regulatory hub involved in gene regulation, chromatin modification, DNA damage repair and signaling. While structures of ...

EMDB-23027: Cryo-EM structure of the human SAGA coactivator ...

Title: Structure of the human SAGA coactivator complex. ... Abstract: The SAGA complex is a regulatory hub involved in gene regulation, chromatin modification, ...

(PDF) Structure of the human SAGA coactivator complex

Our 2.9 Angstrom structure of human SAGA reveals ... [Show full abstract] intertwined functional modules flexibly connected to a core that distinctively ...

Structure of the human SAGA coactivator complex. - Europe PMC

The SAGA complex is a regulatory hub involved in gene regulation, chromatin modification, DNA damage repair and signaling. While structures of yeast SAGA ...

SAGA Complex - The Nogales Lab

Throughout evolution, these TAFs partitioned and specialized into two distinct coactivator complexes in eukaryotes, the general transcription factor TFIID and ...

(PDF) Structure of the human SAGA coactivator complex

It involves the assembly of general transcription factors and RNA polymerase II into a functional pre-initiation complex at core promoters. The ...

8H7G: Cryo-EM structure of the human SAGA complex - RCSB PDB

Cryo-EM structure of human SAGA transcriptional coactivator complex. ; TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor ...

Cryo-EM structure of the SAGA and NuA4 coactivator subunit Tra1 at ...

Both complexes contain the Tra1 subunit, a highly conserved 3744-residue protein from the Phosphoinositide 3-Kinase-related kinase (PIKK) family ...

The Surprising SAGA of a 20-Part Molecular Machine - HHMI

Among such protein complexes, human SAGA is about as big as they come, with 20 component proteins. It belongs to a group of large complexes that ...

Article Molecular Architecture of the S. cerevisiae SAGA Complex

However, the structural homology between TFTC and SAGA remains to be demonstrated, and more importantly, the organization of subunits within these coactivators ...

Human STAGA Complex Is a Chromatin-Acetylating Transcription ...

In accord with the structural similarities of human STAGA to the yeast SAGA coactivator complex, we also have shown that the STAGA complex can be recruited ...

Architecture of the multi‐functional SAGA complex and ... - FEBS Press

SAGA accommodates a nonsymmetric octamer including the seven HF proteins (Fig. 2A). The three-lobed human [[17]] and yeast [[16]] TFIID ...