Structure of the regulatory hyaluronan binding domain in the ...

Structure of the regulatory hyaluronan binding domain in ... - PubMed

Adhesive interactions involving CD44, the cell surface receptor for hyaluronan, underlie fundamental processes such as inflammatory leukocyte homing and ...

Article Structure of the Regulatory Hyaluronan Binding Domain in ...

Here we show using X-ray crystallography and NMR spectroscopy that these sequences form a lobular extension to the Link module, creating an enlarged HA binding ...

Structure of the Regulatory Hyaluronan Binding Domain in ... - CORE

The pendently) both show that residues 21–169 of human. CD44 (i.e., the N-terminal 149 amino acids of the mature observed differences in the ...

Structure of the regulatory hyaluronan binding domain in the ...

Dive into the research topics of 'Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44'. Together they form ...

PDB 1uuh structure summary ‹ Protein Data Bank in Europe (PDBe ...

Hyaluronan binding domain of ... Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44.

Structure of the regulatory hyaluronan binding domain in the ...

Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44. Teriete P 1 ,. Banerji S ,. Noble M ,. Blundell CD ...

Structure of the regulatory hyaluronan binding domain in the ...

Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44. ... Adhesive interactions involving CD44, the cell ...

Supplemental Data Structure of the Regulatory Hyaluronan Binding ...

Conformational Changes upon HA Binding. A ligand-induced change in the hydrogen bond network may also be indicated by the chemical shift changes of C′ ...

The structure and regulation of hyaluronan-binding proteins - PubMed

The structure and regulation of hyaluronan-binding proteins ... Biochem Soc Trans. 1999 Feb;27(2):115-21. doi: 10.1042/bst0270115.

1poz - SOLUTION STRUCTURE OF THE HYALURONAN BINDING ...

Functional Keywords, hyaluronan-binding domain, carbohydrate-binding domain, link module, cell adhesion, glycoprotein ; Biological source, Homo sapiens (human).

Essential hyaluronan structure for binding with ... - ScienceDirect.com

Hyaluronan specifically binds to aggrecan globular domain 1, which is often referred to as just hyaluronan binding protein (HABP), however, ...

Solution Structure of the Link Module: A Hyaluronan-Binding ...

Link modules are hyaluronan-binding domains found in proteins involved in the assembly of extracellular matrix, cell adhesion, and migration.

Hyaluronan-binding Proteins: Tying Up the Giant

The molecular basis of CD44 regulation should become clearer once the tertiary structure of the hyaluronan-binding domain is known, as this will reveal the ...

Revealing the Mechanisms of Protein Disorder and N ... - Frontiers

The structure of the cell surface protein CD44, from its N-terminus to its C-terminus, consists of a globular hyaluronan binding domain (HABD), a stalk domain, ...

Mechanical force effect on the two-state equilibrium of the ... - PNAS

Here, we demonstrate that the force applied from the C terminus of the hyaluronan-binding domain of CD44 stabilized the CD44-mediated rolling.

Molecular Dynamics Simulation Study on Allosteric Regulation of ...

HA molecule and two binding modes, mode-1 and mode-2, of HA on the CD44 HABD surface. Red, yellow, and blue colors on molecular surface denote ...

1uuh - Hyaluronan binding domain of human CD44 - Summary

Hyaluronan binding domain of human CD44 ; Functional Keywords, lectin, hyaluronan, extracellular matrix, receptor, link-domain, c- type lectin, sugar-binding.

Understanding Hyaluronan-Protein Interactions - Glycoforum

Many hyaluronan-binding proteins contain a common domain, termed a Link module, which is involved in ligand binding.

Hyaluronan-binding Proteins - Journal of Biological Chemistry

The molecular basis of CD44 regulation should become clearer once the tertiary structure of the hyaluronan-binding domain is known, as this ...

2JCQ: The hyaluronan binding domain of murine CD44 in a Type A ...

Regulation of transient interactions between cells and the ubiquitous matrix glycosaminoglycan hyaluronan is crucial to such fundamental processes as ...