Study Identifies Factors in Clonal Evolution of Chemotherapy ...

Chemotherapy-treated urothelial carcinoma is enriched with clonal mutations involving L1 cell adhesion molecule (L1CAM) and integrin signaling ...

Clonal Evolution of Chemotherapy-resistant Urothelial Carcinoma

Large genomic studies like The Cancer Genome Atlas (TCGA) have focused only on untreated primary tumors. In particular, the extent to which chemotherapy-treated ...

Identification of Therapy-Induced Clonal Evolution and Resistance ...

Intriguingly, when comparing the genetic and transcriptional dynamics, we found a significant correlation between genetic and nongenetic factors ...

The evolution of hematopoietic cells under cancer therapy - Nature

Moreover, clonal hematopoiesis (CH), a condition related to aging across the human population is known to occur more frequently among people ...

Identification of Therapy-Induced Clonal Evolution and Resistance ...

In multiple myeloma (MM), therapy-induced clonal evolution is associated with treatment resistance and is one of the most important hindrances toward a cure ...

A systematic literature review on clonal evolution events preceding ...

A total of 631 non-duplicate publications were screened of which 28 articles were included for data extraction. Genetic alterations, mutational ...

Evolutionary landscape of clonal hematopoiesis in 3359 ... - Cell Press

Clonal expansion is not dependent on classical cancer risk factors (e.g., smoking). Risk for incident myeloid malignancy diagnosis is highest ...

Monitoring of clonal evolution of acute myeloid leukemia identifies ...

Similarly, in an examination of the genetic mechanisms of primary chemotherapy resistance in pediatric AML, mutations in FRMD8, DHX32, PIK3R1, ...

Adaptation and selection shape clonal evolution of tumors during ...

Tumor recurrence after initial treatment is a frequent cause of death in many cancers, including breast cancer, and recurrent tumors are often ...

Relationship between clonal evolution and drug resistance in ...

External factors include the effects of surgery, chemotherapy, radiotherapy, hormonal therapy, immunotherapy and environmental exposure on tumor heterogeneity.

Clonal transcriptomics identifies mechanisms of chemoresistance ...

This study advances a novel strategy of lineage tracing coupled with single-cell transcriptomics to allow unique insights into tumor heterogeneity.

Clonality in context: hematopoietic clones in their marrow environment

Here we emphasize a view of clonal evolution that stresses natural selection over deterministic ontogeny, and we stress the selective role of the environment of ...

Clonal Evolution: Multiregion Sequencing of Esophageal ...

ITH may be not just predictive of chemotherapy response but also a prognostic factor. A recent study of lung cancer demonstrated that tumors ...

Clonal evolution in chronic lymphocytic leukemia is scant in ...

In order to link evolutionary patterns to different disease courses, we performed a long-term longitudinal mutation profiling study of CLL ...

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood ...

Clonal hematopoiesis was a strong risk factor for subsequent hematologic cancer (hazard ratio, 12.9; 95% confidence interval, 5.8 to 28.7).

Tumour heterogeneity and the evolution of polyclonal drug resistance

Clinical studies with sequential analysis of tumour material are needed to enhance our understanding of inter-clonal functional relationships ...

Landscape of somatic mutations and clonal evolution in mantle cell ...

Some mutations were predominantly clonal or subclonal, indicating an early or late event in tumor evolution, respectively. Our study identifies molecular ...

Genomic landscape and clonal evolution of acute myeloid leukemia ...

005). Together with age and white blood cell counts, JAK2, FLT3-internal tandem duplicationhigh, and KIThigh mutations were identified as ...

Natural and chemotherapy-induced clonal evolution of tumors

In cases of chemotherapy induced clonal evolution of a tumor, chemotherapy becomes the leading factor in treatment. The latest research shows that the impact of ...

Clonal evolution in hematological malignancies and therapeutic ...

Although confirming the basic tenet of cancer as an evolutionary disease, the above described studies are inherently limited in their ability to decipher the ...