Subcellular Force Imbalance in Actin Bundles Induces Nuclear ...

Because the actin cap fibers are anchored to the nucleus at LINC complexes, this effectively isolates the two fiber ends, thereby maintaining ...

Chiam, Bioinformatics Institute, 138671 Singapore, Singapore, E-mail: [email protected] star.edu.sg. KEYWORDS: Durotaxis, traction force, nano/micro pillars, ...

Subcellular Force Imbalance in Actin Bundles Induces Nuclear ...

Subcellular Force Imbalance in Actin Bundles Induces Nuclear Repositioning and Durotaxis ... To read the full-text of this research, you can ...

SUBCELLULAR FORCE IMBALANCE IN ACTIN BUNDLES ...

MYEONGJUN JUN (2022-01-19). SUBCELLULAR FORCE IMBALANCE IN ACTIN BUNDLES INDUCES NUCLEAR REPOSITIONING AND DUROTAXIS. ScholarBank@NUS Repository. URI: https:// ...

Subcellular Force Imbalance in Actin Bundles Induces Nuclear ...

Subcellular Force Imbalance in Actin Bundles Induces Nuclear Repositioning and Durotaxis. https://doi.org/10.1021/acsami.3c07546 ·. Journal: ACS Applied ...

Subcellular Force Imbalance in Actin Bundles Induces Nuclear ...

Subcellular Force Imbalance in Actin Bundles Induces Nuclear Repositioning and Durotaxis. ACS Appl. Mater. Interfaces Pub Date : 2023-09-06. DOI : 10.1021 ...

the importance of nuclear actin dynamics and associated motors for ...

The F-actin bundling protein Fascin was found to bundle nuclear actin filaments to support chromatin organization and a proper DNA damage response (DDR). While ...

Emerging Properties and Functions of Actin and Actin Filaments ...

It is now known that both actin and actin regulatory factors constantly shuttle between the cytosolic and nuclear compartments (Grosse and Vartiainen 2013; ...

Actin on and around the Nucleus: Trends in Cell Biology

However, the compression exerted by actin can cause nuclear rupture. Interactions between the nucleus and actin are studied in vitro using ...

Actin Bundle Nanomechanics and Organization Are Modulated by ...

We have demonstrated through nanoscale imaging and biophysical analysis that cation- and depletion-induced actin bundles can undergo alterations ...

Research article Nuclear pore complexes concentrate on Actin/LINC ...

Actin/LINC/Lamin (ALL) nuclear lines provide mechanical linkage between the actin cytoskeleton and the lamin nucleoskeleton across the nuclear envelope. To ...

Actin Bundles Dynamics and Architecture - MDPI

It is indispensable for driving many cellular processes, including cell migration, cytokinesis, vesicle transport, and contractile force generation [3]. The ...

Description: Regulation of subcellular contractile actin network by ...

SUBCELLULAR FORCE IMBALANCE IN ACTIN BUNDLES INDUCES NUCLEAR REPOSITIONING AND DUROTAXIS by: MYEONGJUN JUN Published: (2022); The regulation of dynamic ...

Spatial coordination between cell and nuclear shape within ... - Nature

Growing evidence suggests that cytoplasmic actin filaments are essential factors in the modulation of nuclear shape and function.

New Insights into Cellular Functions of Nuclear Actin - MDPI

Studies on the nuclear rod formation in Drosophila ovaries showed that cofilin is regulated by nuclear actin-bundling protein fascin [65]. Another protein ...

From stress fiber to focal adhesion: a role of actin crosslinkers in ...

α-Actinin is enriched in the perinuclear actin cap (Shiu et al., 2018), and depletion of α-actinin may reduce force transmission along the perinuclear actin cap ...

Actin Dynamics, Architecture, and Mechanics in Cell Motility

Similar to a branched actin network, elongating actin bundles can exert enough force to move an object (200, 264). In a study using optical traps to measure the ...

Nuclear lamin A/C harnesses the perinuclear apical actin cables to ...

Substrate stretching is a well-designed tool used to apply tensile force to the cell, which enables the monitoring of cellular mechano-responses ...

Confinement hinders motility by inducing RhoA-mediated nuclear ...

Transmission of actomyosin contractile forces to the nucleus is essential for confined migration. When myosin contractility is inhibited, ...

Generation of nuclear actin networks in NIH3T3 cells. Indicated actin...

Here, we demonstrate that fascin bundles F-actin within the nucleus to support chromatin organisation and efficient DDR. Fascin associates directly with ...