- Subgroup analyses in randomised controlled trials🔍
- What a Clinician Ought to Know🔍
- Statistics in Medicine — Reporting of Subgroup Analyses in Clinical ...🔍
- When to believe a subgroup analysis🔍
- How to understand subgroup analysis in clinical studies🔍
- Subgroup analyses in randomized clinical trials🔍
- Statistical Considerations for Subgroup Analyses🔍
- Subgroup Analysis in Randomized Controlled Trials🔍
Subgroup analyses in randomized clinical trials
Subgroup analyses in randomised controlled trials - PubMed
While it is generally recognised that subgroup analyses can produce spurious results, the extent of the problem is almost certainly under-estimated.
What a Clinician Ought to Know: Subgroup Analyses
WHAT ARE SUBGROUP ANALYSES? ... In randomized clinical trials, subgroup analyses evaluate the treatment effect (e.g., a hazard ratio [HR]) for a specific endpoint ...
Statistics in Medicine — Reporting of Subgroup Analyses in Clinical ...
By “subgroup analysis,” we mean any evaluation of treatment effects for a specific end point in subgroups of patients defined by baseline characteristics. The ...
When to believe a subgroup analysis: revisiting the 11 criteria - Nature
Since the included population in an RCT is not homogenous a priori, treatment effects might vary across different subgroups. Thus, assessing ...
How to understand subgroup analysis in clinical studies
Within a study with overall negative conclusions, subgroup analyses might help to avoid «throwing the baby out with the bath water», ...
Subgroup analyses in randomized clinical trials: value and ...
Subgroup analyses in randomized clinical trials: value and limitations. Review #3 on important aspects of randomized clinical trials in cardiovascular ...
Statistical Considerations for Subgroup Analyses - PMC
In RCTs, subgroups are often defined by demographic variables, such as age, sex and race. Subgroups can also be defined by variables that are prognostic of ...
Subgroup Analysis in Randomized Controlled Trials
Randomized clinical trials often use subgroup analyses to explore whether a treatment is more or less effective in a particular patient subgroup ...
Subgroup analyses in randomized controlled trials frequently ...
It is common for subgroup analyses to use continuous variables to define subgroups. The vast majority dichotomize the continuous variable.
Interaction analysis of subgroup effects in randomized trials - Nature
The rationale behind subgroup analysis is to determine how to use a particular treatment most effectively by identifying subgroups of patients ...
Same Old Challenges in Subgroup Analysis—Should We Do More ...
With an average number of 9 subgroup analyses per oncology trial, these subgroup analyses run a high risk of being misled—and misleading their ...
Subgroup analysis in randomised controlled trials: importance ...
Subgroup analyses are important if there are potentially large differences between groups in the risk of a poor outcome with or without treatment.
Subgroup Analysis in Randomized Controlled Trials - ScienceDirect
Randomized clinical trials often use subgroup analyses to explore whether a treatment is more or less effective in a particular patient subgroup.
Full article: Subgroup Analyses in Randomized Clinical Trials
Subgroup analyses should be systematically carried out to identify and quantify predictable and new safety problems that are more commonly observed in subgroups ...
Evaluation of Planned Subgroup Analysis in Protocols of ...
This cross-sectional study compares randomized clinical trial protocols to assess the prevalence and reporting quality of planned subgroup ...
Subgroup analyses in confirmatory clinical trials: time to be specific ...
It is well recognized that treatment effects may not be homogeneous across the study population. Subgroup analyses constitute a fundamental ...
A systematic review of subgroup analyses in randomised clinical ...
Subgroup analyses are frequently used to assess heterogeneity of treatment effects in randomised clinical trials.
Cumulative subgroup analysis to reduce waste in clinical research ...
Subgroup analysis is often used in RCTs to investigate differences in treatment effect between patients with different characteristics [3]. A ...
The influence of study characteristics on reporting of subgroup ...
They also used explicit criteria to determine whether a randomised controlled trial reported subgroup analyses. Logistic regression was used to ...
Understanding of interaction (subgroup) analysis in clinical trials
In randomized clinical trials (RCTs), this type of analysis is typically referred to as subgroup analysis. Although interaction (or subgroup) ...