- Subgroup analyses in randomised controlled trials🔍
- Interaction analysis of subgroup effects in randomized trials🔍
- What a Clinician Ought to Know🔍
- When to believe a subgroup analysis🔍
- On the interpretation of subgroup analyses in randomized trials🔍
- Subgroup analyses in randomized trials🔍
- Statistics in Medicine — Reporting of Subgroup Analyses in Clinical ...🔍
- How to understand subgroup analysis in clinical studies🔍
Subgroup analyses in randomized trials
Subgroup analyses in randomised controlled trials - PubMed
While it is generally recognised that subgroup analyses can produce spurious results, the extent of the problem is almost certainly under-estimated.
Interaction analysis of subgroup effects in randomized trials - Nature
Subgroup analysis aims to identify subgroups (usually defined by baseline/demographic characteristics), who would (or not) benefit from an ...
What a Clinician Ought to Know: Subgroup Analyses
WHAT ARE SUBGROUP ANALYSES? ... In randomized clinical trials, subgroup analyses evaluate the treatment effect (e.g., a hazard ratio [HR]) for a specific endpoint ...
When to believe a subgroup analysis: revisiting the 11 criteria - Nature
The smaller the p-value of the interaction test, the stronger the subgroup effect. For instance, the CATT [14] conducted a non-inferiority trial ...
On the interpretation of subgroup analyses in randomized trials
In randomized trials with subgroup analyses, the primary treatment or intervention of interest is randomized but the secondary factors ...
Subgroup analyses in randomized trials: risks of subgroup-specific ...
Simulations quantified the risks of misinterpreting subgroup analyses as evidence of differential subgroup effects and the limited power of the interaction ...
Statistics in Medicine — Reporting of Subgroup Analyses in Clinical ...
By “subgroup analysis,” we mean any evaluation of treatment effects for a specific end point in subgroups of patients defined by baseline characteristics. The ...
How to understand subgroup analysis in clinical studies
Subgroup analyses in randomized phase III trials of systemic treatments in advanced solid tumours: a systematic review of trials published ...
Subgroup Analysis in Randomized Controlled Trials
Randomized clinical trials often use subgroup analyses to explore whether a treatment is more or less effective in a particular patient subgroup ...
Subgroup analyses in randomized clinical trials: value and ...
Subgroup analyses in randomized clinical trials: value and limitations. Review #3 on important aspects of randomized clinical trials in cardiovascular ...
Subgroup analyses in randomized controlled trials frequently ...
It is common for subgroup analyses to use continuous variables to define subgroups. The vast majority dichotomize the continuous variable.
Subgroup analysis in randomised controlled trials - The Lancet
Subgroup analyses are important if there are potentially large differences between groups in the risk of a poor outcome with or without treatment.
Subgroup Analyses: Subpar or Sublime? | NEJM Evidence - YouTube
This animated video explores some of the potential pitfalls of performing subgroup analyses in randomized controlled trials and explains how ...
Same Old Challenges in Subgroup Analysis—Should We Do More ...
With an average number of 9 subgroup analyses per oncology trial, these subgroup analyses run a high risk of being misled—and misleading their ...
Subgroup analysis in randomised controlled trials: importance ...
Subgroup analyses are important if there are potentially large differences between groups in the risk of a poor outcome with or without treatment.
Evaluation of Planned Subgroup Analysis in Protocols of ...
This cross-sectional study compares randomized clinical trial protocols to assess the prevalence and reporting quality of planned subgroup ...
A systematic review of subgroup analyses in randomised clinical ...
Subgroup analyses are frequently used to assess heterogeneity of treatment effects in randomised clinical trials.
Full article: Subgroup Analyses in Randomized Clinical Trials
Subgroup analyses should be systematically carried out to identify and quantify predictable and new safety problems that are more commonly observed in subgroups ...
Subgroup analyses in confirmatory clinical trials: time to be specific ...
It is well recognized that treatment effects may not be homogeneous across the study population. Subgroup analyses constitute a fundamental ...
The influence of study characteristics on reporting of subgroup ...
They also used explicit criteria to determine whether a randomised controlled trial reported subgroup analyses. Logistic regression was used to ...