Substrate stress relaxation regulates cell migration

Substrate stress relaxation regulates cell spreading - Nature

Here we investigate the influence of ECM stress relaxation on cell behaviour through computational modelling and cellular experiments.

Substrate stress relaxation regulates monolayer fluidity and leader ...

While tissue viscoelasticity is a ubiquitous feature of biological tissues, its role in mediating collective cell migration is unclear. Here, we ...

Enhanced substrate stress relaxation promotes filopodia-mediated ...

1: Substrate stress relaxation regulates cell migration on soft substrates. figure 1. a, Young's modulus of three different formulations of ...

Substrate stress relaxation regulates cell migration | Stanford Digital ...

Cell migration plays an important role during many biological processes including embryogenesis, wound healing, immune trafficking and ...

Substrate Stress Relaxation Regulates Cell Migration - JScholarship

Mechanical stimuli from the extracellular matrix (ECM) play an essential role in regulating important biological processes including cell spreading, ...

Substrate stress relaxation regulates cell spreading - PubMed

Studies of cellular mechanotransduction have converged upon the idea that cells sense extracellular matrix (ECM) elasticity by gauging ...

Substrate stress relaxation regulates neural stem cell fate commitment

In particular, ECM elastic properties such as stiffness have been shown to affect cell migration (1–3), adhesion (4, 5), and differentiation (6– ...

Substrate Stress Relaxation Regulates Cell Migration - ProQuest

We find that cancer cells can migrate through matrices with sufficient mechanical plasticity without requiring protease activity.

Enhanced substrate stress relaxation promotes filopodia-mediated ...

These observations result from adherent cell migration studies on stiff, elastic substrates, because most cells do not migrate on soft, elastic substrates.

Substrate stress relaxation regulates cell spreading - ResearchGate

Download Citation | Substrate stress relaxation regulates cell spreading | Studies of cellular mechanotransduction have converged upon the idea that cells ...

Substrate stress relaxation regulates cell spreading. - H1 Connect

Studies of cellular mechanotransduction have converged upon the idea that cells sense extracellular matrix (ECM) elasticity by gauging resistance to the tr.

Enhanced substrate stress relaxation promotes filopodia-mediated ...

These observations result from adherent cell migration studies on stiff, elastic substrates, because most cells do not migrate on soft, elastic ...

Gradual Stress-Relaxation of Hydrogel Regulates Cell Spreading

... Substrate stress relaxation regulates cell spreading. Nat. Commun. 2015, 6 ... Matrix mechanical plasticity regulates cancer cell migration through confining ...

[PDF] Dynamic freedom: substrate stress relaxation stimulates cell ...

... migration, and discusses the potential of exploiting engineered fibrous ... Substrate stress relaxation regulates cell spreading · Ovijit ChaudhuriLuo Gu

A multiscale whole-cell theory for mechanosensitive migration on ...

Third, migration is regulated by the cell-level reaction ... substrate stress relaxation on the HT-1080 cell migration behavior (38).

Substrate stress relaxation regulates cell spreading - OUCI

& Griffith, L. G. Cell adhesion and motility depend on nanoscale RGD clustering. J. Cell Sci. 113, (Pt 10): 1677–1686 (2000).

Focal adhesion-mediated directional cell migration guided by ...

11. Sacco, P. ∙ Baj, G. ∙ Asaro, F. ... Substrate Dissipation Energy Regulates Cell Adhesion and Spreading ... Enhanced substrate stress relaxation promotes ...

Substrate stress relaxation regulates cell spreading - Harvard DASH

Surprisingly, both our computational model and experiments find that spreading for cells cultured on soft substrates that exhibit stress relaxation is greater ...

Unified multiscale theory of cellular mechanical adaptations to ...

Substrate stress relaxation regulates cell spreading. Nat. Commun., 6 ... Enhanced substrate stress relaxation promotes filopodia-mediated cell migration.

Hydrogels with tunable stress relaxation regulate stem cell fate and ...

It is found that cell spreading, proliferation, and osteogenic differentiation of mesenchymal stem cells (MSCs) are all enhanced in cells cultured in gels with ...