Susceptibility to innate immune activation in genetically|mediated ...

Susceptibility to innate immune activation in genetically mediated ...

EHTs replicate electrical and contractile phenotypes seen in human myocarditis, implicating cytokine release as a key part of the myogenic susceptibility to ...

Susceptibility to innate immune activation in genetically mediated ...

Myocarditis is clinically characterized by chest pain, arrhythmias, and heart failure, and treatment is often supportive.

Susceptibility to innate immune activation in genetically ... - JCI

Susceptibility to innate immune activation in genetically-mediated myocarditis. Daniel F. Selgrade, Kathleen J. Green, Elizabeth M. McNally.

Susceptibility to innate immune activation in genetically mediated ...

Myocarditis is clinically characterized by chest pain, arrhythmias, and heart failure, and treatment is often supportive. Mutations in DSP, a gene encoding ...

Susceptibility to innate immune activation in genetically mediated ...

Susceptibility to innate immune activation in genetically mediated myocarditis. J Clin Invest. 2024 May 16; 134(13). View in: PubMed. subject areas.

Susceptibility to innate immune activation in genetically-mediated ...

Susceptibility to innate immune activation in genetically-mediated myocarditis. Abstract. Myocarditis is clinically characterized by chest pain, arrhythmias ...

Susceptibility to innate immune activation in genetically-mediated ...

At baseline, DSP-/- EHTs displayed a transcriptomic signature of innate immune activation, which was mirrored by cytokine release. Importantly, ...

Dynamic innate immune response determines susceptibility to ...

These results show that the activity of ISG-mediated defenses at the time of SARS-CoV-2 exposure impacts infection progression and that the ...

Pathogen-specific innate immune response patterns are distinctly ...

Innate immune responses vary by pathogen and host genetics. We analyze quantitative trait loci (eQTLs) and transcriptomes of monocytes from 215 individuals.

Extensive innate immune gene activation accompanies brain aging ...

Microglial and perivascular macrophages are the principal effector cells driving the innate immune response in the brain. While microglia and ...

Recent human genetic errors of innate immunity leading to ...

Human inborn errors of innate immunity can present as increased susceptibility to infection with a narrow range of pathogens. · Non-hematopoietic tissue resident ...

Genetic and epigenetic dysregulation of innate immune ...

Dysregulation and hyperactivation of innate immune responses can lead to the onset of systemic autoinflammatory diseases.

Validating genetic variants in innate immunity linked to infectious ...

Discussion. Multiple SNPs of the innate immune system have been suspected to alter the susceptibility to infectious events in patients with AML.

DNA Sensing in the Innate Immune Response | Physiology

Because DNA is the carrier of genetic information for a wide range of life forms, including microbes, the innate immune system has evolved ...

Germline Genetic Variants of Viral Entry and Innate Immunity May ...

Several SNPs within the scope of our approach were found to alter susceptibility to various bacterial and viral infections. Additionally, a multitude of studies ...

Identification of innate immunity genes and pathways using ... - PNAS

However, excessive activation of the innate immune response can contribute to many immunological diseases, including asthma, atherosclerosis, and sepsis (2–4).

Regulation of DAF-16-mediated Innate Immunity in Caenorhabditis ...

Activation of the innate immune system results in a rapid microbicidal response against microorganisms, which needs to be fine-tuned because uncontrolled immune ...

The role of innate immune genes in Alzheimer's disease

Genome-wide association studies (GWAS) have identified many Alzheimer's disease risk genes related to immune response and microglia including the phagocytic ...

Biology of the Immune System - Beutler Lab

These tactics, collectively termed the innate immune response, are employed against all classes of microbe irrespective of prior exposure, and are the vanguard ...

Innate immune disorders - Immune Deficiency Foundation

Innate immune disorders include Myd88 and IRAK-4 deficiencies, TLR3 deficiency, NF-kappa-B essential modulator (NEMO) deficiency syndrome, natural killer (NK) ...