Susceptibility to innate immune activation in genetically mediated ...

EHTs replicate electrical and contractile phenotypes seen in human myocarditis, implicating cytokine release as a key part of the myogenic susceptibility to ...

Myocarditis is clinically characterized by chest pain, arrhythmias, and heart failure, and treatment is often supportive.

Susceptibility to innate immune activation in genetically ... - JCI

Susceptibility to innate immune activation in genetically mediated myocarditis ... Citation Information: J Clin Invest. 2024;134(13):e180254.

Susceptibility to innate immune activation in genetically mediated ...

EHTs replicate electrical and contractile phenotypes seen in human myocarditis, implicating cytokine release as a key part of the myogenic susceptibility to ...

Susceptibility to innate immune activation in genetically mediated ...

Susceptibility to innate immune activation in genetically mediated myocarditis. J Clin Invest. 2024 May 16; 134(13). View in: PubMed. subject areas.

Susceptibility to innate immune activation in genetically mediated ...

Susceptibility to innate immune activation in genetically mediated myocarditis. by Daniel F Selgrade, Dominic E Fullenkamp, Ivana A Chychula, Binjie Li, ...

Susceptibility to innate immune activation in genetically-mediated ...

At baseline, DSP-/- EHTs displayed a transcriptomic signature of innate immune activation, which was mirrored by cytokine release. Importantly, ...

Susceptibility to innate immune activation in genetically-mediated ...

Susceptibility to innate immune activation in genetically-mediated myocarditis. Daniel F Selgrade, Dominic E Fullenkamp, Ivana A Chychula, Binjie Li, Lisa ...

Susceptibility to innate immune activation in genetically mediated ...

Dive into the research topics of 'Susceptibility to innate immune activation in genetically mediated myocarditis'. Together they form a unique fingerprint. Sort ...

Pathogen-specific innate immune response patterns are distinctly ...

Innate immune responses vary by pathogen and host genetics. We analyze quantitative trait loci (eQTLs) and transcriptomes of monocytes from 215 individuals.

Dynamic innate immune response determines susceptibility to ...

These results show that the activity of ISG-mediated defenses at the time of SARS-CoV-2 exposure impacts infection progression and that the ...

Recent human genetic errors of innate immunity leading to ...

Human inborn errors of innate immunity can present as increased susceptibility to infection with a narrow range of pathogens. · Non-hematopoietic tissue resident ...

Activation of R‐mediated innate immunity and disease susceptibility ...

Upon infection, mutants lacking functional OASTL-A1 in both genetic backgrounds showed an enhanced infection rate, concomitant with higher ...

Validating genetic variants in innate immunity linked to infectious ...

Discussion. Multiple SNPs of the innate immune system have been suspected to alter the susceptibility to infectious events in patients with AML.

Extensive innate immune gene activation accompanies brain aging ...

While there is evidence that TLR signaling can mediate some beneficial effects in CNS [54, 70], it is believed that TLR-induced activation of ...

Germline Genetic Variants of Viral Entry and Innate Immunity May ...

Several SNPs within the scope of our approach were found to alter susceptibility to various bacterial and viral infections. Additionally, a multitude of studies ...

Regulation of DAF-16-mediated Innate Immunity in Caenorhabditis ...

Activation of the innate immune system results in a rapid microbicidal response against microorganisms, which needs to be fine-tuned because uncontrolled ...

Innate immunity - Journal of Allergy and Clinical Immunology

Human mutations and polymorphisms in many of the genes encoding elements of these pathways appear to alter susceptibility to infectious and inflammatory ...

Identification of innate immunity genes and pathways using ... - PNAS

However, excessive activation of the innate immune response can contribute to many immunological diseases, including asthma, atherosclerosis, and sepsis (2–4).

Impact of genetic polymorphisms related to innate immune response ...

Polymorphisms in the genes of immune system is considered as an important aspect behind the resistance or susceptibility of the host to an ...